Covalent attachment of macromolecules to polysulfones or polyethersulfones modified to contain functionalizable chain ends
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United States of America Patent
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Oct 31, 1995
Issued Date -
N/A
app pub date -
Feb 2, 1994
filing date -
Oct 17, 1988
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Abstract
A hydrophobic polymer such as polysulfone or polyethersulfone is modified to contain an increased number of functionalizable chain ends such as by treating with an alkali hydroxide to provide hydroxyl groups. A linker is covalently bonded to a chain end of the polymer and a macromolecule is covalently bonded to the linker. A ligand may be covalently bonded to the macromolecule. The macromolecule can be a natural polymer, a synthetic polymer or a biologically active species. The hydrophobic polymer is preferably in the form of a microporous membrane. By the use of a four-component dope composition, substantially isotropic microporous structures in the form of flat sheets or hollow fibers are produced. An improved spinnerette assembly is provided for the production of hollow fibers.
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