Specific inhibitors of tissue kallikrein
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United States of America Patent
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Nov 7, 1995
Grant Date -
N/A
app pub date -
Jun 22, 1993
filing date -
Jun 22, 1993
priority date (Note) -
Expired
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Abstract
The invention is directed to substrate analogs which are specific for tissue kallikrein. These analogs contain a sequence which corresponds to at least positions 388 to 390 of human kininogen, and which has a 4-aminophenylalanine (Phe(4NH.sub.2)), or a structurally or functionally similar residue, corresponding to position 389. These substrate analogs are useful in compositions and methods for the treatment or prevention of biological activities associated with tissue kallikrein including inflammation, the regulation of blood flow, the regulation of proenzyme activity through processing, shock, hypotension, vascular leakage, and the perception of pain.
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