Conjugates of superoxide dismutage coupled to high molecular weight polyalkylene glycols
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United States of America Patent
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Nov 21, 1995
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N/A
app pub date -
Oct 18, 1993
filing date -
Aug 3, 1987
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Abstract
A biologically persistent, water-soluble, substantially non-immunogenic, substantially non-antigenic conjugate of superoxide dismutase is prepared by coupling one to five strands of a polyalkylene glycol which is polyethylene glycol or polyethylene-polypropylene glycol copolymer, wherein said polyalkylene glycol has an average molecular weight of about 35,000-1,000,000.
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