Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 5468613
SERIAL NO

07491210

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Single or multiple nucleotide variations in nucleic acid sequence can be detected in nucleic acids by a process whereby the sample suspected of containing the relevant nucleic acid is repeatedly treated with primers, nucleotide triphosphates, and an agent for polymerization of the triphosphates and then denatured, in a process which amplifies the sequence containing the nucleotide variation if it is present. In one embodiment, the sample is spotted on a membrane and treated with a labeled sequence-specific oligonucleotide probe. Hybridization of the probe to the sample is detected by the label on the probe.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ROCHE MOLECULAR SYSTEMS, INC.PLEASANTON, CA375

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Erlich, Henry A Oakland, CA 27 6950
Horn, Glenn Emeryville, CA 6 1658
Mullis, Kary B Kensington, CA 32 11113
Saiki, Randall K Richmond, CA 23 7941

Cited Art Landscape

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