US Patent No: 5,468,613

Number of patents in Portfolio can not be more than 2000

Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids

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Abstract

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Single or multiple nucleotide variations in nucleic acid sequence can be detected in nucleic acids by a process whereby the sample suspected of containing the relevant nucleic acid is repeatedly treated with primers, nucleotide triphosphates, and an agent for polymerization of the triphosphates and then denatured, in a process which amplifies the sequence containing the nucleotide variation if it is present. In one embodiment, the sample is spotted on a membrane and treated with a labeled sequence-specific oligonucleotide probe. Hybridization of the probe to the sample is detected by the label on the probe.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ROCHE MOLECULAR SYSTEMS, INC.PLEASANTON, CA338

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Erlich, Henry A Oakland, CA 27 6485
Horn, Glenn Emeryville, CA 6 1541
Mullis, Kary B Kensington, CA 32 10372
Saiki, Randall K Richmond, CA 23 7376

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