14 and/or 15-hydroxy 6,9 hemiacetal erythromycin derivatives
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United States of America Patent
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Nov 28, 1995
Grant Date -
N/A
app pub date -
Mar 19, 1993
filing date -
Mar 19, 1992
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Disclosed are (1) a structurally novel 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof, which has an excellent gastrointestinal function promoting effect and is low in toxicity; (2) a process for preparing a 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof, which comprises reacting a 6,9-hemiacetal-erythromycin derivative or a salt thereof with an organism-derived oxidase; and (3) a gastrointestinal function promoting agent containing a 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof.
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