Pro-urokinase mutants
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United States of America Patent
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Dec 5, 1995
Grant Date -
N/A
app pub date -
Jul 2, 1993
filing date -
Jul 2, 1993
priority date (Note) -
Expired
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Abstract
The invention relates to thrombolytically active pro-urokinase (pro-UK) mutants comprising the amino acid sequence of native pro-UK, but including a mutation which causes the pro-UK mutants to induce less fibrinogenolysis and non-specific plasminogen activation than native pro-UK, to have at least a 10-fold lower intrinsic activity than native pro-UK, and to have substantially the same fibrin promotion and thrombolytic activity after plasmin activation compared to native pro-UK when administered to a patient.
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