Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other opioid agonists
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United States of America Patent
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Dec 5, 1995
Issued Date -
N/A
app pub date -
Jul 27, 1993
filing date -
Sep 21, 1992
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Abstract
This invention relates to a method of selectively enhancing the analgesic potency of morphine and other clinically used bimodally-acting opioid agonists and simultaneously attenuating development of physical dependence, tolerance and other undesirable side-effects caused by the chronic administration of said bimodally-acting opioid agonists comprising the co-administration of a bimodally-acting opioid agonist which activates inhibitory opioid receptor-mediated functions of neurons in the nociceptive (pain) pathways of the nervous system and an opioid receptor antagonist which selectively inactivates excitatory opioid receptor-mediated side-effects caused by said bimodally-acting opioid agonists. This invention further relates to a method of detoxifying and treating opiate addicts utilizing said opioid receptor antagonists, as well as to a composition comprising an excitatory opioid receptor antagonist of the invention and a bimodally-acting opioid agonist.
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