Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
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United States of America Patent
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Dec 12, 1995
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app pub date -
Mar 26, 1993
filing date -
Mar 26, 1993
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Abstract
The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) ##STR1## with .beta.-lactams of formula (V). ##STR2## The invention also provides pharmaceutical compositions including the novel taxanes and method for treatment of certain cancers with these new compounds.
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