Nucleic acid ligands
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United States of America Patent
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Dec 12, 1995
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N/A
app pub date -
Jun 10, 1991
filing date -
Jun 11, 1990
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Abstract
A new class of nucleic acid compounds, referred to as nucleic acid ligands, have been shown to exist that have a specific binding affinity for three dimensional molecular targets. In a preferred embodiment the nucleic acid ligands are identified by the method of the invention referred to as the Systematic Evolution of Ligands by EXponential enrichment (SELEX), wherein a candidate mixture of nucleic acids are iteratively enriched in high affinity nucleic acids and amplified for further partitioning.
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