Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control

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United States of America Patent

PATENT NO 5475610
SERIAL NO

07871264

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow through the block controls the block temperature. Constant bias cooling is used for small changes. Sample temperature is calculated instead of measured. A platen deforms plastic caps to apply a minimum acceptable threshold force for seating the tubes and thermally isolates them. A cover isolates the block. The control software includes diagnostics. An install program tests and characterizes the instrument. A new user interface is used. Disposable, multipiece plastic microtiter trays to give individual freedom to sample tubes are taught.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
APPLIED BIOSYSTEMS, LLCFOSTER CITY, CA976

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Atwood, John G West Redding, CT 27 848
Goven, Lisa M Bridgeport, CT 2 439
Leath, Richard Berkley, CA 12 721
Margoulies, Marcel Scarsdale, NY 2 286
Miles, Clive San Rafael, CA 13 673
Mossa, Albert C Trumbull, CT 2 439
Ragusa, Robert P Newton, CT 31 1673
Williams, Fenton Brookfield, CT 10 589
Woudenberg, Timothy M Bethel, CT 56 2293

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