Ligands of thrombin
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United States of America Patent
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Dec 19, 1995
Issued Date -
N/A
app pub date -
Nov 6, 1992
filing date -
Jun 11, 1990
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Abstract
Methods are described for the identification of nuclei acid ligand solutions to thrombin. The present invention utilizes the SELEX (Systematic Evolution of Ligands for EXponential enrichment) method for identifying and preparing RNA ligands to thrombin. Further included in the present invention are modified nucleotide sequences based on the sequences of the RNA ligands identified. The modified RNA ligands to thrombin exhibit increased in vivo stability.
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