Peptide production
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United States of America Patent
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Dec 19, 1995
Issued Date -
N/A
app pub date -
Aug 18, 1992
filing date -
Jun 30, 1986
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method of producing a proteinaceous compound, involves incorporating a DNA sequence coding for polypeptide into a gene of a mammal (such as a sheep) coding for a milk whey protein in such a way that the DNA sequence is expressed in the mammary gland of the adult female mammal. The proteinaceous compound may be a (optionally modified) protein such as a blood coagulation factor. The DNA sequence is preferably inserted into the first exon of a gene coding for a whey protein such as beta-lactoglobulin. The proteinaceous compound will generally be recovered from milk of the female mammal, but may (for example if it is an enzyme) be used in situ.
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