Nucleic acid probe for the detection of Salmonella human pathogens
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United States of America Patent
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Jan 23, 1996
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May 17, 1994
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Feb 13, 1989
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Abstract
Nucleic acid probes that detect Salmonella human pathogens are generated from the nucleotide sequences of a gene encoding a virulence factor involved in the pathogenesis of Salmonella, especially the Type 1 fimbriae protein. Preferred probe lengths are about 20 to about 100 nucleotide bases. The probes are highly specific and sensitive for detecting Salmonella organisms pathogenic to humans and are thus clinically useful in the detection of infection in diarrhea specimens. They also may be used in the detection of food-borne Salmonella, the causative agent of most salmonellosis in humans.
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