Process for making optically active alpha-amino ketones and selected novel optically active alpha-amino ketones
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United States of America Patent
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Jan 30, 1996
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Apr 22, 1994
filing date -
Jun 15, 1992
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Abstract
The invention includes selected novel optically active .alpha.-amino ketones which either are themselves useful or are intermediates for the preparation of known ketomethylene pseudopeptides useful as antibiotics, antibiotic enhancers, or enzyme inhibitors. Further, the present invention provides a method for dehydrogenation/asymmetrical hydrogenation to obtain essentially pure antipodes of ketomethylene pseudopeptides having two chiral centers.
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