US Patent No: 5,490,962

Number of patents in Portfolio can not be more than 2000

Preparation of medical devices by solid free-form fabrication methods

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Abstract

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Solid free-form techniques for making medical devices for controlled release of bioactive agent and implantation and growth of Cells are described using computer aided design. Examples of SFF methods include stereo-lithography (SLA), selective laser sintering (SLS), ballistic particle manufacturing (BPM), fusion deposition modeling (FDM), and three dimensional printing (3DP). The macrostructure and porosity of the device can be manipulated by controlling printing parameters. Most importantly, these features can be designed and tailored using computer assisted design (CAD) for individual patients to optimize therapy.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
MASSACHUSETTS INSTITUTE OF TECHNOLOGYCAMBRIDGE, MA2667

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cima, Linda G Lexington, MA 11 973
Cima, Michael J Winchester, MA 168 3743

Cited Art Landscape

Patent Info (Count) # Cites Year
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (2)
* 4,485,097 Bone-equivalent and method for preparation thereof 212 1983
* 5,204,055 Three-dimensional printing techniques 390 1989
 
MESOBLAST INTERNATIONAL SÀRL (2)
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* 5,226,914 Method for treating connective tissue disorders 286 1990
 
TEXAS INSTRUMENTS INCORPORATED (1)
* 5,260,009 System, method, and process for making three-dimensional objects 111 1992
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
* 4,520,821 Growing of long-term biological tissue correction structures in vivo 199 1982
 
Other [Check patent profile for assignment information] (2)
* 4,609,551 Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites 200 1984
* 4,620,327 Process of adapting soluble bone protein for use in stimulating osteoinduction 83 1984
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
3D SYSTEMS, INC. (23)
* 5,817,206 Selective laser sintering of polymer powder of controlled particle size distribution 26 1996
* 5,902,441 Method of three dimensional printing 73 1996
6,416,850 Three dimensional printing materials system 70 1999
6,610,429 Three dimensional printing material system and method 47 2001
7,087,109 Three dimensional printing material system and method 32 2002
7,332,537 Three dimensional printing material system and method 13 2003
7,291,002 Apparatus and methods for 3D printing 5 2004
7,569,273 Thermoplastic powder material system for appearance models from 3D printing systems 3 2004
7,550,518 Methods and compositions for three-dimensional printing of solid objects 3 2005
7,261,542 Apparatus for three dimensional printing using image layers 29 2005
7,435,368 Three-dimensional printer 8 2006
7,795,349 Material systems and methods of three-dimensional printing 0 2006
7,979,152 Apparatus and methods for handling materials in a 3-D printer 2 2007
7,971,991 Apparatus and methods for handling materials in a 3-D printer 0 2007
7,828,022 Apparatus and methods for handling materials in a 3-D printer 4 2007
7,905,951 Three dimensional printing material system and method using peroxide cure 1 2007
8,167,999 Three-dimensional printing material system with improved color, article performance, and ease of use 0 2008
7,968,626 Three dimensional printing material system and method using plasticizer-assisted sintering 1 2008
7,686,995 Three-dimensional printer 2 2008
8,017,055 Three-dimensional printer 3 2010
8,157,908 Three dimensional printing material system and method using peroxide cure 0 2011
8,506,862 Three dimensional printing material system and method using plasticizer-assisted sintering 0 2011
8,185,229 Apparatus and methods for handling materials in a 3-D printer 2 2011
 
WARSAW ORTHOPEDIC, INC. (23)
7,163,691 Bone graft 36 2002
7,662,185 Intervertebral implants 6 2003
7,726,002 Processes for making spinal intervertebral implant, interconnections for such implant 0 2004
8,328,876 Bone matrix compositions and methods 0 2004
8,333,985 Non-glycerol stabilized bone graft 0 2005
7,780,708 Implant retaining device 7 2005
8,663,672 Osteoimplant and method of making same 0 2005
8,268,008 Osteoimplants and methods for their manufacture 1 2006
7,959,941 Bone graft comprising a demineralized bone matrix and a stabilizing agent 5 2007
8,545,864 Hemostatic bone graft 0 2007
7,939,108 Method of making demineralized bone particles 1 2007
8,372,157 Joint revision implant 0 2008
8,734,525 Osteoinductive demineralized cancellous bone 0 2008
8,642,061 Method of treating bone tissue 0 2008
8,357,384 Bone matrix compositions and methods 0 2008
8,202,539 Demineralized bone matrix compositions and methods 0 2008
8,002,813 Volume maintaining osteoinductive/osteoconductive compositions 2 2009
8,722,075 Compositions and methods for promoting bone formation 0 2009
8,672,980 Implant retaining device 0 2010
8,529,962 Method of making demineralized bone particles 0 2011
8,197,474 Volume maintaining osteoinductive/osteoconductive compositions 1 2011
8,435,566 Demineralized bone matrix compositions and methods 0 2012
8,753,689 Method of making demineralized bone particles 0 2013
 
REVA MEDICAL, INC. (16)
7,763,065 Balloon expandable crush-recoverable stent device 17 2004
8,292,944 Slide-and-lock stent 4 2004
7,914,574 Axially nested slide and lock expandable device 3 2005
8,277,500 Slide-and-lock stent 7 2006
7,722,662 Expandable stent with sliding and locking radial elements 18 2006
7,704,275 Circumferentially nested expandable device 19 2007
8,034,365 N-substituted monomers and polymers 0 2007
7,988,721 Axially-radially nested expandable device 9 2007
7,947,071 Expandable slide and lock stent 19 2009
8,172,894 Circumferentially nested expandable device 19 2010
8,512,394 Balloon expandable crush-recoverable stent device 3 2010
8,617,235 Axially nested slide and lock expandable device 3 2011
8,523,936 Expandable slide and lock stent 3 2011
8,545,547 Expandable slide and lock stent 3 2011
8,460,363 Axially-radially nested expandable device 0 2011
8,540,762 Circumferentially nested expandable device 3 2012
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (14)
* 6,530,958 Tissue regeneration matrices by solid free-form fabrication techniques 82 1995
* 5,797,898 Microchip drug delivery devices 344 1996
* 6,123,861 Fabrication of microchip drug delivery devices 196 1998
7,070,590 Microchip drug delivery devices 20 2000
6,730,072 Methods and devices for sealing microchip reservoir devices 33 2001
6,514,518 Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof 29 2001
* 7,931,914 System and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form 1 2002
8,088,415 Diffusion-controlled dosage form and method of fabrication including three dimensional printing 1 2003
7,918,842 Medical device with controlled reservoir opening 2 2004
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7,815,826 Manufacturing process, such as three-dimensional printing, including solvent vapor filming and the like 9 2005
7,901,397 Method for operating microchip reservoir device 1 2007
8,758,658 System and method for uniaxial compression of an article, such as a three dimensionally printed dosage form 0 2010
8,465,777 Diffusion-controlled dosage form and method of fabrication including three dimensional printing 0 2011
 
SHIONOGI INC. (14)
7,122,204 Antibiotic composition with inhibitor 3 2003
8,425,936 Antibiotic product, use and formulation thereof 0 2004
8,313,775 Antibiotic product, use and formulation thereof 0 2004
8,313,776 Antibiotic product, use and formulation thereof 0 2004
8,758,820 Robust pellet 0 2004
8,062,672 Antibiotic product, use and formulation thereof 0 2004
8,246,996 Antibiotic product, use and formulation thereof 0 2004
8,715,727 Tablet for pulsed delivery 0 2005
7,282,221 Antiviral product, use and formulation thereof 2 2005
8,778,924 Modified release amoxicillin products 0 2006
8,357,394 Compositions and methods for improved efficacy of penicillin-type antibiotics 0 2006
8,299,052 Pharmaceutical compositions and methods for improved bacterial eradication 0 2007
8,303,988 Antifungal once-a-day product, use and formulation thereof 0 2010
8,889,187 Once a day amoxicillin product comprising immediate and delayed release dosage forms 0 2011
 
GENESIS MICROCHIP INC. (12)
6,527,762 Thermally-activated microchip chemical delivery devices 82 2000
6,551,838 Microfabricated devices for the storage and selective exposure of chemicals and devices 136 2001
6,849,463 Microfabricated devices for the storage and selective exposure of chemicals and devices 65 2002
* 6,669,683 Thermally-activated microchip chemical delivery devices 116 2003
7,413,846 Fabrication methods and structures for micro-reservoir devices 22 2004
7,497,846 Hermetically sealed microchip reservoir devices 4 2004
7,537,590 Multi-reservoir device for transdermal drug delivery and sensing 17 2005
7,604,628 Multi-cap reservoir devices for controlled release or exposure of reservoir contents 3 2005
7,488,316 Control of drug release by transient modification of local microenvironments 2 2006
7,445,766 Medical device and method for diagnostic sensing 3 2006
8,016,817 Device for controlling exposure of reservoir contents to surroundings 0 2009
8,403,915 Multi-opening reservoir devices for controlled release or exposure of reservoir contents 0 2009
 
EXONE GMBH (11)
8,741,194 Method for producing a part using a depostion technique 0 2000
7,204,684 Interchangeable container 17 2001
7,004,222 Device for manufacturing models layer by layer 25 2001
7,879,393 Method and device for applying fluids 3 2002
7,531,117 Method for constructing patterns in a layered manner 1 2003
7,807,077 Methods and systems for the manufacture of layered three-dimensional forms 2 2004
8,020,604 Method for the layered construction of models 1 2004
7,137,431 Device for pattern building in layers 15 2005
8,506,870 Methods of manufacturing layered three-dimensional forms 0 2008
7,955,537 Method for constructing patterns in a layered manner 0 2009
8,122,939 Method for the layered construction of models 0 2011
 
Cardiac Pacemakers, Inc. (9)
8,271,093 Systems and methods for deriving relative physiologic measurements using a backend computing system 6 2004
7,742,815 Using implanted sensors for feedback control of implanted medical devices 9 2005
7,955,268 Multiple sensor deployment 0 2007
8,725,260 Methods of monitoring hemodynamic status for rhythm discrimination within the heart 0 2009
8,369,960 Systems and methods for controlling wireless signal transfers between ultrasound-enabled medical devices 0 2009
8,591,423 Systems and methods for determining cardiac output using pulmonary artery pressure measurements 0 2009
8,632,470 Assessment of pulmonary vascular resistance via pulmonary artery pressure 0 2009
7,949,394 Using implanted sensors for feedback control of implanted medical devices 0 2010
8,852,099 Systems and methods for deriving relative physiologic measurements 0 2012
 
GEORGIA TECH RESEARCH CORPORATION (7)
8,002,830 Surface directed cellular attachment 5 2005
7,910,124 Load bearing biocompatible device 5 2005
8,142,808 Method of treating joints with hydrogel implants 3 2008
7,682,540 Method of making hydrogel implants 22 2008
8,318,192 Method of making load bearing hydrogel implants 2 2008
8,895,073 Hydrogel implant with superficial pores 0 2011
8,486,436 Articular joint implant 0 2012
 
MICRODOSE THERAPEUTX, INC. (7)
* 5,960,609 Metering and packaging method and device for pharmaceuticals and drugs 22 1998
6,923,979 Method for depositing particles onto a substrate using an alternating electric field 9 1999
6,428,809 Metering and packaging of controlled release medication 10 1999
6,702,683 Metering and packaging of controlled release medication 6 2002
7,404,968 Metering and packaging of controlled release medication 34 2004
7,632,533 Method and apparatus for producing uniform small portions of fine powders and articles thereof 6 2007
8,439,033 Inhalation device 0 2008
 
MICRON TECHNOLOGY, INC. (7)
6,432,752 Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages 40 2000
6,791,164 Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages 6 2002
6,593,171 Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages 41 2002
6,514,798 Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages 37 2002
6,770,514 Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages 4 2003
6,890,801 Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages 1 2003
6,951,779 Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages 1 2004
 
THE INVENTION SCIENCE FUND I, LLC (7)
8,340,944 Computational and/or control systems and methods related to nutraceutical agent selection and dosing 0 2006
8,297,028 Individualized pharmaceutical selection and packaging 0 2006
7,927,787 Methods and systems for analysis of nutraceutical associated components 0 2006
7,827,042 Methods and systems related to transmission of nutraceutical associated information 0 2007
7,974,856 Computational systems and methods related to nutraceuticals 0 2007
8,068,991 Systems and methods for transmitting pathogen related information and responding 0 2007
8,000,981 Methods and systems related to receiving nutraceutical associated information 2 2007
 
THE UNIVERSITY OF LIVERPOOL (7)
* 7,537,664 Laser-produced porous surface 8 2003
8,728,387 Laser-produced porous surface 0 2005
8,147,861 Antimicrobial implant 0 2006
8,350,186 Laser-produced implants 0 2006
8,268,099 Laser-produced porous surface 0 2009
8,556,981 Laser-produced porous surface 1 2009
8,268,100 Laser-produced porous surface 1 2010
 
VOXELJET AG (6)
8,096,262 Method and device for applying fluids 0 2005
7,767,130 Method and device for production of a three-dimensional article 4 2005
7,736,578 Method for the construction of a laminated compound 3 2007
8,727,672 Method and device for conveying particulate material during the layer-wise production of patterns 0 2008
8,715,832 Method for the layered construction of plastic models 0 2009
7,927,539 Method for the construction of a laminated compound 1 2010
 
THEKEN SPINE, LLC (5)
6,213,168 Apparatus and method for dispensing of powders 10 1999
6,454,811 Composites for tissue regeneration and methods of manufacture thereof 112 1999
6,341,952 Fabrication of tissue products with additives by casting or molding using a mold formed by solid free-form methods 14 2001
* 6,772,026 System and method for rapidly customizing design, manufacture and/or selection of biomedical devices 161 2001
7,122,057 Method and apparatus for engineered regenerative biostructures such as hydroxyapatite substrates for bone healing applications 28 2002
 
REMON MEDICAL TECHNOLOGIES LTD. (4)
7,621,905 Devices for intrabody delivery of molecules and systems and methods utilizing same 17 2003
7,813,808 Implanted sensor system with optimized operational and sensing parameters 1 2005
7,641,619 Barometric pressure correction based on remote sources of information 12 2007
7,948,148 Piezoelectric transducer 4 2009
 
STRATASYS LTD. (4)
7,300,619 Compositions and methods for use in three dimensional model printing 8 2003
7,851,122 Compositions and methods for use in three dimensional model printing 4 2008
8,106,107 Compositions and methods for use in three dimensional model printing 3 2010
8,883,392 Compositions and methods for use in three dimensional model printing 0 2013
 
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (4)
* 7,666,445 Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use 0 2001
8,741,327 Method of maintaining therapeutic risperidone levels in a PLA:PLGA implant 0 2006
8,758,795 Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use 0 2009
8,802,127 Risperidone-containing PLA:PGA implants and methods of use thereof 0 2012
 
ETHICON, INC. (3)
* 5,674,921 Radiation-curable, urethane-acrylate prepolymers and crosslinked polymers 25 1995
* 6,147,135 Fabrication of biocompatible polymeric composites 25 1998
6,303,697 Fabrication of biocompatible polymeric composites 25 2000
 
KENSEY NASH CORPORATION (3)
* 7,963,997 Device for regeneration of articular cartilage and other tissue 4 2004
8,795,242 Resorbable polymeric device for localized drug delivery 0 2005
8,403,996 Device for regeneration of articular cartilage and other tissue 0 2006
 
PENTRON CLINICAL TECHNOLOGIES, LLC (3)
* 6,322,728 Mass production of dental restorations by solid free-form fabrication methods 141 1999
6,821,462 Mass production of shells and models for dental restorations produced by solid free-form fabrication methods 38 2001
6,808,659 Solid free-form fabrication methods for the production of dental restorations 47 2001
 
3M INNOVATIVE PROPERTIES COMPANY (2)
8,535,580 Digitally forming a dental model for fabricating orthodontic laboratory appliances 0 2008
8,738,165 Methods of preparing a virtual dentition model and fabricating a dental retainer therefrom 0 2008
 
BALISTRERI, JOHN (2)
* 8,568,649 Three-dimensional printer, ceramic article and method of manufacture 0 2007
8,475,946 Ceramic article and method of manufacture 0 2007
 
BOSTON SCIENTIFIC SCIMED, INC. (2)
6,641,776 Method for preparing radiopaque surgical implement 5 2000
7,041,130 Stent for controlled release of drug 83 2004
 
INTERNATIONAL BRACHYTHERAPY, S.A. (2)
* 6,086,942 Fluid-jet deposition of radioactive material for brachytherapy devices 43 1998
6,461,433 Fluid-jet deposition of radioactive material 3 2000
 
NOVARTIS AG (2)
7,235,195 Method for making opthalmic devices 6 2003
7,860,594 Method for making opthalmic devices 4 2007
 
SMED-TA/TD, LLC (2)
8,475,505 Orthopaedic screws 1 2009
8,702,767 Orthopaedic Screws 0 2013
 
THERICS, LLC (2)
6,547,994 Rapid prototyping and manufacturing process 29 1999
6,336,480 Apparatus and method for dispensing of powders 14 2001
 
TREDEGAR INDUSTRIES, INC. (2)
6,471,992 Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same 11 1998
* 6,280,771 Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof 32 1998
 
VOXELJET GMBH (2)
7,665,636 Device for feeding fluids 2 2003
8,349,233 Material system and method for changing properties of a plastic component 0 2008
 
WAKE FOREST UNIVERSITY HEALTH SCIENCES (2)
8,834,520 Devices and methods for treating spinal cord tissue 0 2008
* 8,764,794 Device and method for treating central nervous system pathology 0 2012
 
ADVANCIS PHARMACEUTICAL CORPORATION (1)
8,460,710 Antibiotic product, use and formulation thereof 0 2004
 
AMS RESEARCH CORPORATION (1)
6,991,647 Bioresorbable stent 64 2001
 
APRECIA PHARMACEUTICALS COMPANY (1)
8,888,480 Three-dimensional printing system and equipment assembly 0 2013
 
BIOMET MANUFACTURING, LLC (1)
* 8,679,191 Continuous phase composite for musculoskeletal repair 0 2011
 
CLEMSON UNIVERSITY (1)
7,051,654 Ink-jet printing of viable cells 12 2003
 
FIN-CERAMICA FAENZA S.P.A. (1)
* 8,172,907 Method for the production of a biologically active prosthetic device for the reconstruction of bone tissue and the prosthetic device itself 0 2005
 
GSLE SUBCO L.L.C. (1)
6,796,770 Impeller and method using solid free form fabrication 3 2002
 
JENERIC/PENTRON INCORPORATED (1)
6,994,549 Dental restorations formed by solid free-form fabrication methods 34 2001
 
MASSACHUSETTS EYE & EAR INFIRMARY (1)
7,563,255 Implantable drug delivery device and use thereof 12 2002
 
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (1)
7,718,109 Tissue support structure 1 2006
 
OBJET GEOMETRIES LTD. (1)
7,479,510 Compositions and methods for use in three dimensional model printing 4 2006
 
PENTRON LABORATORY TECHNOLOGIES, LLC (1)
7,563,397 Solid free-form fabrication methods for the production of dental restorations 15 2004
 
POREX SURGICAL (1)
8,142,886 Porous laser sintered articles 0 2008
 
RENEURON, INC. (1)
* 5,762,959 Microencapsulation of cells 21 1994
 
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (1)
8,288,590 N-substituted monomers and polymers 0 2011
 
Sanders Prototypes, Inc. (1)
* 5,740,051 3-D model making 87 1995
 
SANDIA CORPORATION (1)
6,993,406 Method for making a bio-compatible scaffold 21 2004
 
SEIKO EPSON CORPORATION (1)
* 7,892,607 Multilayer film, electrooptic device, electronic apparatus, and process for forming multilayer film 0 2006
 
SPX CORPORATION (1)
7,056,095 Impeller and method using solid free form fabrication 4 2004
 
STRATASYS, INC. (1)
* 5,653,925 Method for controlled porosity three-dimensional modeling 79 1995
 
SUZUKI, MAMORU (1)
6,932,610 Process for producing an artificial bone model and an artificial bone model produced by the process 16 2003
 
Tethon Corporation (1)
* 8,845,953 Three-dimensional printer, ceramic article and method of manufacture 0 2013
 
THE CURATORS OF THE UNIVERSITY OF MISSOURI (1)
8,703,216 Engineered comestible meat 0 2012
 
THE REGENTS OF THE UNIVERSITY OF MICHIGAN (1)
7,509,240 Solid freeform fabrication of structurally engineered multifunctional devices 3 2002
 
TREDEGER CORPORATION (1)
6,261,493 Fabrication of tissue products with additives by casting or molding using a mold formed by solid free-form methods 8 1998
 
UNITED STATES GYPSUM COMPANY (1)
8,323,429 Method for preparing three-dimensional plaster objects 0 2009
 
UNITED TECHNOLOGIES CORPORATION (1)
6,228,437 Method for modifying the properties of a freeform fabricated part 22 1999
 
VIVEX BIOMEDICAL, INC. (1)
8,864,839 Bone implants and method of manufacture 0 2013
 
Other [Check patent profile for assignment information] (6)
* 5,590,454 Method and apparatus for producing parts by layered subtractive machine tool techniques 12 1994
* 7,147,666 Monolithic implants with openings 2 1997
6,593,008 Modified freeform fabricated part and a method for modifying the properties of a freeform fabricated part 3 2002
8,912,247 Hydrophilic/hydrophobic polymer networks based on poly(caprolactone fumarate), poly(ethylene glycol fumarate), and copolymers thereof 0 2006
8,911,759 Bone matrix compositions and methods 0 2006
8,911,226 Device for producing three-dimensional models 0 2011
* Cited By Examiner