Preparation of medical devices by solid free-form fabrication methods

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 5490962
SERIAL NO

08138345

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Solid free-form techniques for making medical devices for controlled release of bioactive agent and implantation and growth of Cells are described using computer aided design. Examples of SFF methods include stereo-lithography (SLA), selective laser sintering (SLS), ballistic particle manufacturing (BPM), fusion deposition modeling (FDM), and three dimensional printing (3DP). The macrostructure and porosity of the device can be manipulated by controlling printing parameters. Most importantly, these features can be designed and tailored using computer assisted design (CAD) for individual patients to optimize therapy.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
MASSACHUSETTS INSTITUTE OF TECHNOLOGYCAMBRIDGE, MA3151

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cima, Linda G Lexington, MA 10 1215
Cima, Michael J Lexington, MA 125 5105

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* Cited By Examiner

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* 7892607 Multilayer film, electrooptic device, electronic apparatus, and process for forming multilayer film 0 2006
 
KENSEY NASH CORPORATION (9)
* 7963997 Device for regeneration of articular cartilage and other tissue 4 2004
* 2004/0197,311 Device for regeneration of articular cartilage and other tissue 38 2004
8795242 Resorbable polymeric device for localized drug delivery 0 2005
* 2005/0177,118 Resorbable polymeric device for localized drug delivery 36 2005
8403996 Device for regeneration of articular cartilage and other tissue 0 2006
* 2010/0331,979 Biphasic implant device transmitting mechanical stimulus 5 2009
* 2010/0331,865 Biphasic implant device providing joint fluid therapy 0 2009
* 2010/0330,181 Biphasic implant device providing gradient 1 2009
* 2010/0331,998 Electrokinetic device for tissue repair 1 2009
 
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (1)
* 2011/0212,501 3-DIMENSIONAL MULTI-LAYERED HYDROGELS AND METHODS OF MAKING THE SAME 16 2009
 
MICRON TECHNOLOGY, INC. (7)
6432752 Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages 40 2000
6791164 Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages 6 2002
6593171 Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages 41 2002
6514798 Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages 39 2002
6770514 Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages 4 2003
6890801 Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages 1 2003
6951779 Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages 1 2004
 
The University of Liverpool (17)
* 7537664 Laser-produced porous surface 61 2003
* 2004/0191,106 Laser-produced porous surface 28 2003
* 2006/0147,332 Laser-produced porous structure 94 2004
8728387 Laser-produced porous surface 34 2005
* 2007/0142,914 Laser-produced porous surface 79 2005
8147861 Antimicrobial implant 42 2006
8350186 Laser-produced implants 4 2006
8268099 Laser-produced porous surface 39 2009
* 2009/0286,008 Laser-produced porous surface 1 2009
8556981 Laser-produced porous surface 5 2009
8268100 Laser-produced porous surface 41 2010
* 2010/0291,286 LASER-PRODUCED POROUS SURFACE 6 2010
9456901 Laser-produced porous structure 0 2010
* 2011/0014,081 LASER-PRODUCED POROUS STRUCTURE 42 2010
9135374 Surface modified unit cell lattice structures for optimized secure freeform fabrication 0 2012
8992703 Laser-produced porous surface 0 2012
9180010 Surface modified unit cell lattice structures for optimized secure freeform fabrication 0 2012
 
XEROX CORPORATION (5)
* 9381154 Direct inkjet fabrication of drug delivery devices 0 2011
* 9415546 System and method for controlling material drop volume in three dimensional object printing 0 2014
* 2015/0210,011 System And Method For Controlling Material Drop Volume In Three Dimensional Object Printing 1 2014
9446556 System for compensating for drop volume variation during three-dimensional printing of an object 0 2014
9327537 System for adjusting operation of a printer during three-dimensional object printing using an optical sensor 0 2014
 
MASSACHUSETTS EYE & EAR INFIRMARY (3)
7563255 Implantable drug delivery device and use thereof 20 2002
* 2006/0167,435 Transscleral drug delivery device and related methods 21 2004
* 2005/0175,708 Drug delivery systems and use thereof 31 2004
 
Voxeijet AG (2)
8992205 Device for the layer-wise production of patterns 1 2008
8956144 Device for producing three-demensional models 1 2011
 
EX ONE CORPORATION (1)
* 2010/0168,890 Three-Dimensional Data Extraction Using Ray Casting 1 2005
 
PENTRON LABORATORY TECHNOLOGIES, LLC (3)
7563397 Solid free-form fabrication methods for the production of dental restorations 30 2004
* 2004/0262,797 Solid free-form fabrication methods for the production of dental restorations 3 2004
* 2005/0110,177 Mass production of shells and models for dental restorations produced by solid free-form fabrication methods 14 2004
 
MICRODENTAL TECHNOLOGIES, INC. (1)
* 2010/0092,923 Methods for production of dental prosthetics 0 2009
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (21)
* 6530958 Tissue regeneration matrices by solid free-form fabrication techniques 111 1995
* 5797898 Microchip drug delivery devices 422 1996
* 6123861 Fabrication of microchip drug delivery devices 227 1998
7070590 Microchip drug delivery devices 34 2000
6730072 Methods and devices for sealing microchip reservoir devices 36 2001
6514518 Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof 37 2001
9463160 Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same 0 2002
* 7931914 System and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form 4 2002
* 2003/0143,268 System and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form 32 2002
8088415 Diffusion-controlled dosage form and method of fabrication including three dimensional printing 1 2003
7918842 Medical device with controlled reservoir opening 5 2004
* 7892221 Method of controlled drug delivery from implant device 1 2005
7815826 Manufacturing process, such as three-dimensional printing, including solvent vapor filming and the like 19 2005
* 2008/0032,083 Manufacturing Process, Such as Three-Dimensional Printing, Including Solvent Vapor Filming and the Like 12 2005
* 2006/0189,963 MULTI-RESERVOIR DEVICE FOR CONTROLLED DRUG DELIVERY 4 2006
7901397 Method for operating microchip reservoir device 2 2007
* 2008/0051,766 Method for Operating Microchip Reservoir Device 2 2007
8758658 System and method for uniaxial compression of an article, such as a three dimensionally printed dosage form 0 2010
* 2011/0187,015 System and method for uniaxial compression of an article, such as a three dimensionally printed dosage form 0 2010
8465777 Diffusion-controlled dosage form and method of fabrication including three dimensional printing 0 2011
9114072 Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same 0 2012
 
PENTRON CLINICAL TECHNOLOGIES, LLC (5)
* 6322728 Mass production of dental restorations by solid free-form fabrication methods 224 1999
6821462 Mass production of shells and models for dental restorations produced by solid free-form fabrication methods 57 2001
* 2002/0064,745 Mass production of shells and models for dental restorations produced by solid free-form fabrication methods 5 2001
6808659 Solid free-form fabrication methods for the production of dental restorations 67 2001
* 2002/0125,592 Solid free-form fabrication methods for the production of dental restorations 8 2001
 
THERICS, INC. (2)
* 2004/0062,814 Method and materials for controlling migration of binder liquid in a powder 8 2003
* 2004/0091,516 Printing or dispensing a suspension such as three-dimensional printing of dosage forms 0 2003
 
THERICS, LLC (6)
6547994 Rapid prototyping and manufacturing process 36 1999
6336480 Apparatus and method for dispensing of powders 20 2001
* 2003/0114,936 Complex three-dimensional composite scaffold resistant to delimination 99 2002
* 2004/0243,481 System and method for rapidly customizing design, manufacture and/or selection of biomedical devices 203 2004
* 2005/0177,237 Spinal cage insert, filler piece and method of manufacturing 20 2004
* 2005/0085,922 Shaped filler for implantation into a bone void and methods of manufacture and use thereof 9 2004
 
SEARETE LLC (9)
* 2007/0289,258 Individualized pharmaceutical selection and packaging 8 2006
* 2007/0124,219 Computational and/or control systems related to individualized nutraceutical selection and packaging 0 2006
* 2007/0124,218 Computational and/or control systems related to individualized nutraceutical selection and packaging 0 2006
* 2007/0174,128 Computational and/or control systems related to individualized pharmaceutical and nutraceutical selection and packaging 1 2006
* 2007/0136,092 Computational and/or control systems related to individualized pharmaceutical and nutraceutical selection and packaging 10 2006
* 2007/0124,176 Computational and/or control systems and methods related to nutraceutical agent selection and dosing 3 2006
* 2008/0114,577 Computational methods and systems associated with nutraceutical related assays 0 2007
* 2008/0052,114 Computational systems and methods related to nutraceuticals 0 2007
* 2008/0103,746 Systems and methods for pathogen detection and response 1 2007
 
Vaxdesign Corporation (1)
* 2008/0111,282 Process for Making Three Dimensional Objects From Dispersions of Polymer Colloidal Particles 16 2006
 
CARTIVA, INC. (3)
* 2005/0278,025 Meniscus prosthesis 38 2004
9155543 Tapered joint implant and related tools 1 2012
9526632 Methods of repairing a joint using a wedge-shaped implant 0 2015
 
INSTITUT FUR POLYMERFORSCHUNG DRESDEN E.V. (1)
* 2008/0233,302 Method and Device for Production of a Three-Dimensional Article 5 2005
 
REGENTS OF THE UNIVERSITY OF MICHIGAN, THE (1)
7509240 Solid freeform fabrication of structurally engineered multifunctional devices 6 2002
 
STRATASYS LTD. (10)
7300619 Compositions and methods for use in three dimensional model printing 15 2003
* 2004/0187,714 Compositons and methods for use in three dimensional model printing 18 2003
7479510 Compositions and methods for use in three dimensional model printing 13 2006
7851122 Compositions and methods for use in three dimensional model printing 8 2008
* 2009/0105,363 COMPOSITIONS AND METHODS FOR USE IN THREE DIMENSIONAL MODEL PRINTING 5 2008
8106107 Compositions and methods for use in three dimensional model printing 6 2010
* 2011/0077,321 COMPOSITIONS AND METHODS FOR USE IN THREE DIMENSIONAL MODEL PRINTING 4 2010
8932511 Method of making a composite material by three-dimensional ink-jet printing 0 2011
8883392 Compositions and methods for use in three dimensional model printing 0 2013
9334402 Compositions and methods for use in three dimensional model printing 0 2014
 
3M INNOVATIVE PROPERTIES COMPANY (3)
8535580 Digitally forming a dental model for fabricating orthodontic laboratory appliances 0 2008
8738165 Methods of preparing a virtual dentition model and fabricating a dental retainer therefrom 4 2008
* 2011/0091,832 RAPID PROTOTYPED TRANSFER TRAY FOR ORTHODONTIC APPLIANCES 0 2009
 
GENESIS MICROCHIP INC. (10)
* 2006/0093,646 Orthopedic and dental implant devices providing controlled drug delivery 102 2005
* 2007/0016,163 MEDICAL AND DENTAL IMPLANT DEVICES FOR CONTROLLED DRUG DELIVERY 68 2006
* 2007/0088,442 PASSIVE WEAR-INDICATING SENSOR FOR IMPLANTABLE PROSTHETIC DEVICE 23 2006
* 2007/0275,035 Minimally Invasive Medical Implant Devices for Controlled Drug Delivery 87 2007
* 2008/0015,494 MULTI-RESERVOIR PUMP DEVICE FOR DIALYSIS, BIOSENSING, OR DELIVERY OF SUBSTANCES 69 2007
* 2008/0076,975 METHOD AND IMPLANTABLE DEVICE WITH RESERVOIR ARRAY FOR PRE-CLINICAL IN VIVO TESTING 4 2007
* 2008/0083,041 Pre-Clinical Animal Testing Method 8 2007
* 2009/0024,113 MULTI-RESERVOIR MEDICAL DEVICE HAVING PROTECTED INTERIOR WALLS 1 2008
* 2009/0142,386 CONTROL OF DRUG RELEASE BY TRANSIENT MODIFICATION OF LOCAL MICROENVIRONMENTS 1 2009
* 2009/0234,214 MULTI-RESERVOIR DEVICE AND METHOD FOR TRANSDERMAL SENSING 2 2009
 
The Curators of the University of Missouri (1)
8703216 Engineered comestible meat 1 2012
 
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (5)
9255178 Photocrosslinkable poly (caprolactone fumarate) 0 2005
7718109 Tissue support structure 19 2006
* 2006/0249,875 Tissue support structure 3 2006
8912247 Hydrophilic/hydrophobic polymer networks based on poly(caprolactone fumarate), poly(ethylene glycol fumarate), and copolymers thereof 0 2006
* 2008/0262,102 Hydrophilic/Hydrophobic Polymer Networks Based on Poly(Caprolactone Fumarate), Poly(Ethylene Glycol Fumarate), and Copolymers Thereof 2 2006
 
Mamoru Suzuki (1)
* 2004/0175,686 Process for producing an artificial bone model and an artificial bone model produced by the process 3 2003
 
SPX FLOW, INC. (3)
6796770 Impeller and method using solid free form fabrication 5 2002
7056095 Impeller and method using solid free form fabrication 6 2004
* 2006/0110,256 IMPELLER AND METHOD USING SOLID FREE FORM FABRICATION 5 2004
 
Z CORPORATION (4)
* 2005/0059,757 Absorbent fillers for three-dimensional printing 18 2004
* 2006/0230,984 Three dimensional printing material system and method 14 2006
* 2007/0241,482 Production of three-dimensional objects by use of electromagnetic radiation 28 2007
* 2008/0252,682 Apparatus and Methods for Servicing 3D Printers 1 2008
 
THEKEN SPINE, LLC (8)
6213168 Apparatus and method for dispensing of powders 13 1999
6454811 Composites for tissue regeneration and methods of manufacture thereof 158 1999
6341952 Fabrication of tissue products with additives by casting or molding using a mold formed by solid free-form methods 16 2001
* 6772026 System and method for rapidly customizing design, manufacture and/or selection of biomedical devices 265 2001
* 2002/0059,049 System and method for rapidly customizing design, manufacture and/or selection of biomedical devices 204 2001
7122057 Method and apparatus for engineered regenerative biostructures such as hydroxyapatite substrates for bone healing applications 44 2002
* 2003/0065,400 Method and apparatus for engineered regenrative biostructures such as hydroxyapatite substrates for bone healing applications 17 2002
* 2007/0009,606 Manufacturing process, such as three dimensional printing, including binding of water-soluble material followed by softening and flowing and forming films of organic-solvent-soluble material 4 2005
 
ADAMS, ROBERT W. (1)
* 2015/0250,715 PROCESS FOR MAKING CONTROLLED RELEASE MEDICAL IMPLANT PRODUCTS 0 2013
 
WAKE FOREST UNIVERSITY (5)
8834520 Devices and methods for treating spinal cord tissue 0 2008
9289193 Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage 0 2009
9131927 Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage 0 2009
* 8764794 Device and method for treating central nervous system pathology 0 2012
9050136 External fixation assembly and method of use 1 2013
 
BIOMET MANUFACTURING, LLC (3)
* 8679191 Continuous phase composite for musculoskeletal repair 1 2011
* 2011/0190,903 CONTINUOUS PHASE COMPOSITE FOR MUSCULOSKELETAL REPAIR 3 2011
9456905 Continuous phase composite for musculoskeletal repair 0 2014
 
BOSTON SCIENTIFIC SCIMED, INC. (7)
6641776 Method for preparing radiopaque surgical implement 7 2000
6991647 Bioresorbable stent 108 2001
7041130 Stent for controlled release of drug 105 2004
* 2004/0260,391 Stent for controlled release of drug 12 2004
* 2004/0247,671 Solid drug formulation and device for storage and controlled delivery thereof 73 2004
* 9440003 Medical devices having particle-containing regions with diamond-like coatings 0 2005
* 2007/0106,363 Medical devices having particle-containing regions with diamond-like coatings 27 2005
 
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (1)
* 2011/0129,924 Porous Polymeric Articles 2 2006
 
EXONE GMBH (18)
8741194 Method for producing a part using a depostion technique 5 2000
7204684 Interchangeable container 43 2001
7004222 Device for manufacturing models layer by layer 36 2001
7879393 Method and device for applying fluids 9 2002
7531117 Method for constructing patterns in a layered manner 9 2003
* 2004/0035,542 Device for manufacturing models layer by layer 17 2003
* 2004/0026,418 Interchangeable container 9 2003
* 2004/0170,765 Method and device for applying fluids 36 2004
7807077 Methods and systems for the manufacture of layered three-dimensional forms 4 2004
8020604 Method for the layered construction of models 2 2004
* 2005/0167,872 Method for constructing patterns in a layered manner 29 2005
7137431 Device for pattern building in layers 24 2005
* 2006/0108,090 Device for pattern building in layers 3 2005
8506870 Methods of manufacturing layered three-dimensional forms 2 2008
* 2008/0237,933 Methods and systems for manufacturing the manufacture of layered three-dimensional forms 8 2008
7955537 Method for constructing patterns in a layered manner 2 2009
8122939 Method for the layered construction of models 1 2011
9403324 Method for producing a part using a deposition technique 0 2014
 
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (1)
8288590 N-substituted monomers and polymers 0 2011
* Cited By Examiner