US Patent No: 5,490,962

Number of patents in Portfolio can not be more than 2000

Preparation of medical devices by solid free-form fabrication methods

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Abstract

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Solid free-form techniques for making medical devices for controlled release of bioactive agent and implantation and growth of Cells are described using computer aided design. Examples of SFF methods include stereo-lithography (SLA), selective laser sintering (SLS), ballistic particle manufacturing (BPM), fusion deposition modeling (FDM), and three dimensional printing (3DP). The macrostructure and porosity of the device can be manipulated by controlling printing parameters. Most importantly, these features can be designed and tailored using computer assisted design (CAD) for individual patients to optimize therapy.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
MASSACHUSETTS INSTITUTE OF TECHNOLOGYCAMBRIDGE, MA2990

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cima, Linda G Lexington, MA 10 1149
Cima, Michael J Lexington, MA 122 4775

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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* Cited By Examiner

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Patent Info (Count) # Cites Year
 
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9,358,056 Orthopaedic implant 0 2009
* 2010/0042,214 DRUG DELIVERY IMPLANTS 10 2009
* 2010/0042,215 ORTHOPAEDIC IMPLANT 18 2009
8,702,767 Orthopaedic Screws 0 2013
9,408,699 Removable augment for medical implant 0 2014
 
SEIKO EPSON CORPORATION (1)
* 7,892,607 Multilayer film, electrooptic device, electronic apparatus, and process for forming multilayer film 0 2006
 
KENSEY NASH CORPORATION (9)
* 7,963,997 Device for regeneration of articular cartilage and other tissue 4 2004
* 2004/0197,311 Device for regeneration of articular cartilage and other tissue 37 2004
8,795,242 Resorbable polymeric device for localized drug delivery 0 2005
* 2005/0177,118 Resorbable polymeric device for localized drug delivery 35 2005
8,403,996 Device for regeneration of articular cartilage and other tissue 0 2006
* 2010/0331,979 Biphasic implant device transmitting mechanical stimulus 4 2009
* 2010/0331,865 Biphasic implant device providing joint fluid therapy 0 2009
* 2010/0330,181 Biphasic implant device providing gradient 1 2009
* 2010/0331,998 Electrokinetic device for tissue repair 1 2009
 
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (1)
* 2011/0212,501 3-DIMENSIONAL MULTI-LAYERED HYDROGELS AND METHODS OF MAKING THE SAME 11 2009
 
Micron Technology, Inc. (7)
6,432,752 Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages 40 2000
6,791,164 Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages 6 2002
6,593,171 Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages 41 2002
6,514,798 Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages 38 2002
6,770,514 Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages 4 2003
6,890,801 Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages 1 2003
6,951,779 Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages 1 2004
 
THE UNIVERSITY OF LIVERPOOL (15)
* 7,537,664 Laser-produced porous surface 38 2003
* 2004/0191,106 Laser-produced porous surface 26 2003
8,728,387 Laser-produced porous surface 16 2005
* 2007/0142,914 Laser-produced porous surface 50 2005
8,147,861 Antimicrobial implant 23 2006
8,350,186 Laser-produced implants 3 2006
8,268,099 Laser-produced porous surface 21 2009
* 2009/0286,008 Laser-produced porous surface 1 2009
8,556,981 Laser-produced porous surface 5 2009
8,268,100 Laser-produced porous surface 23 2010
* 2010/0291,286 LASER-PRODUCED POROUS SURFACE 5 2010
* 2011/0014,081 LASER-PRODUCED POROUS STRUCTURE 24 2010
9,135,374 Surface modified unit cell lattice structures for optimized secure freeform fabrication 0 2012
8,992,703 Laser-produced porous surface 0 2012
9,180,010 Surface modified unit cell lattice structures for optimized secure freeform fabrication 0 2012
 
XEROX CORPORATION (4)
* 9,381,154 Direct inkjet fabrication of drug delivery devices 0 2011
* 9,415,546 System and method for controlling material drop volume in three dimensional object printing 0 2014
* 2015/0210,011 System And Method For Controlling Material Drop Volume In Three Dimensional Object Printing 1 2014
9,327,537 System for adjusting operation of a printer during three-dimensional object printing using an optical sensor 0 2014
 
MASSACHUSETTS EYE & EAR INFIRMARY (3)
7,563,255 Implantable drug delivery device and use thereof 19 2002
* 2006/0167,435 Transscleral drug delivery device and related methods 20 2004
* 2005/0175,708 Drug delivery systems and use thereof 29 2004
 
Voxeijet AG (2)
8,992,205 Device for the layer-wise production of patterns 1 2008
8,956,144 Device for producing three-demensional models 1 2011
 
EX ONE CORPORATION (1)
* 2010/0168,890 Three-Dimensional Data Extraction Using Ray Casting 1 2005
 
Pentron Laboratory Technologies, LLC (3)
7,563,397 Solid free-form fabrication methods for the production of dental restorations 27 2004
* 2004/0262,797 Solid free-form fabrication methods for the production of dental restorations 1 2004
* 2005/0110,177 Mass production of shells and models for dental restorations produced by solid free-form fabrication methods 13 2004
 
MICRODENTAL TECHNOLOGIES, INC. (1)
* 2010/0092,923 Methods for production of dental prosthetics 0 2009
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (20)
* 6,530,958 Tissue regeneration matrices by solid free-form fabrication techniques 105 1995
* 5,797,898 Microchip drug delivery devices 402 1996
* 6,123,861 Fabrication of microchip drug delivery devices 220 1998
7,070,590 Microchip drug delivery devices 29 2000
6,730,072 Methods and devices for sealing microchip reservoir devices 34 2001
6,514,518 Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof 35 2001
* 7,931,914 System and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form 3 2002
* 2003/0143,268 System and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form 29 2002
8,088,415 Diffusion-controlled dosage form and method of fabrication including three dimensional printing 1 2003
7,918,842 Medical device with controlled reservoir opening 5 2004
* 7,892,221 Method of controlled drug delivery from implant device 1 2005
7,815,826 Manufacturing process, such as three-dimensional printing, including solvent vapor filming and the like 17 2005
* 2008/0032,083 Manufacturing Process, Such as Three-Dimensional Printing, Including Solvent Vapor Filming and the Like 10 2005
* 2006/0189,963 MULTI-RESERVOIR DEVICE FOR CONTROLLED DRUG DELIVERY 4 2006
7,901,397 Method for operating microchip reservoir device 1 2007
* 2008/0051,766 Method for Operating Microchip Reservoir Device 2 2007
8,758,658 System and method for uniaxial compression of an article, such as a three dimensionally printed dosage form 0 2010
* 2011/0187,015 System and method for uniaxial compression of an article, such as a three dimensionally printed dosage form 0 2010
8,465,777 Diffusion-controlled dosage form and method of fabrication including three dimensional printing 0 2011
9,114,072 Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same 0 2012
 
PENTRON CLINICAL TECHNOLOGIES, LLC (5)
* 6,322,728 Mass production of dental restorations by solid free-form fabrication methods 194 1999
6,821,462 Mass production of shells and models for dental restorations produced by solid free-form fabrication methods 51 2001
* 2002/0064,745 Mass production of shells and models for dental restorations produced by solid free-form fabrication methods 2 2001
6,808,659 Solid free-form fabrication methods for the production of dental restorations 62 2001
* 2002/0125,592 Solid free-form fabrication methods for the production of dental restorations 4 2001
 
THERICS, INC. (2)
* 2004/0062,814 Method and materials for controlling migration of binder liquid in a powder 8 2003
* 2004/0091,516 Printing or dispensing a suspension such as three-dimensional printing of dosage forms 0 2003
 
THERICS, LLC (6)
6,547,994 Rapid prototyping and manufacturing process 33 1999
6,336,480 Apparatus and method for dispensing of powders 15 2001
* 2003/0114,936 Complex three-dimensional composite scaffold resistant to delimination 91 2002
* 2004/0243,481 System and method for rapidly customizing design, manufacture and/or selection of biomedical devices 180 2004
* 2005/0177,237 Spinal cage insert, filler piece and method of manufacturing 12 2004
* 2005/0085,922 Shaped filler for implantation into a bone void and methods of manufacture and use thereof 5 2004
 
SEARETE LLC (9)
* 2007/0289,258 Individualized pharmaceutical selection and packaging 8 2006
* 2007/0124,219 Computational and/or control systems related to individualized nutraceutical selection and packaging 0 2006
* 2007/0124,218 Computational and/or control systems related to individualized nutraceutical selection and packaging 0 2006
* 2007/0174,128 Computational and/or control systems related to individualized pharmaceutical and nutraceutical selection and packaging 1 2006
* 2007/0136,092 Computational and/or control systems related to individualized pharmaceutical and nutraceutical selection and packaging 10 2006
* 2007/0124,176 Computational and/or control systems and methods related to nutraceutical agent selection and dosing 3 2006
* 2008/0114,577 Computational methods and systems associated with nutraceutical related assays 0 2007
* 2008/0052,114 Computational systems and methods related to nutraceuticals 0 2007
* 2008/0103,746 Systems and methods for pathogen detection and response 1 2007
 
VAXDESIGN CORPORTATION (1)
* 2008/0111,282 Process for Making Three Dimensional Objects From Dispersions of Polymer Colloidal Particles 11 2006
 
CARTIVA, INC (2)
* 2005/0278,025 Meniscus prosthesis 36 2004
9,155,543 Tapered joint implant and related tools 0 2012
 
Institut fur Polymerforschung E.V. Dresden (1)
* 2008/0233,302 Method and Device for Production of a Three-Dimensional Article 3 2005
 
THE REGENTS OF THE UNIVERSITY OF MICHIGAN (1)
7,509,240 Solid freeform fabrication of structurally engineered multifunctional devices 6 2002
 
STRATASYS LTD. (10)
7,300,619 Compositions and methods for use in three dimensional model printing 11 2003
* 2004/0187,714 Compositons and methods for use in three dimensional model printing 11 2003
7,479,510 Compositions and methods for use in three dimensional model printing 8 2006
7,851,122 Compositions and methods for use in three dimensional model printing 7 2008
* 2009/0105,363 COMPOSITIONS AND METHODS FOR USE IN THREE DIMENSIONAL MODEL PRINTING 2 2008
8,106,107 Compositions and methods for use in three dimensional model printing 3 2010
* 2011/0077,321 COMPOSITIONS AND METHODS FOR USE IN THREE DIMENSIONAL MODEL PRINTING 1 2010
8,932,511 Method of making a composite material by three-dimensional ink-jet printing 0 2011
8,883,392 Compositions and methods for use in three dimensional model printing 0 2013
9,334,402 Compositions and methods for use in three dimensional model printing 0 2014
 
3M INNOVATIVE PROPERTIES COMPANY (3)
8,535,580 Digitally forming a dental model for fabricating orthodontic laboratory appliances 0 2008
8,738,165 Methods of preparing a virtual dentition model and fabricating a dental retainer therefrom 1 2008
* 2011/0091,832 RAPID PROTOTYPED TRANSFER TRAY FOR ORTHODONTIC APPLIANCES 0 2009
 
GENESIS MICROCHIP INC. (6)
* 2006/0093,646 Orthopedic and dental implant devices providing controlled drug delivery 93 2005
* 2007/0016,163 MEDICAL AND DENTAL IMPLANT DEVICES FOR CONTROLLED DRUG DELIVERY 61 2006
* 2008/0015,494 MULTI-RESERVOIR PUMP DEVICE FOR DIALYSIS, BIOSENSING, OR DELIVERY OF SUBSTANCES 60 2007
* 2009/0024,113 MULTI-RESERVOIR MEDICAL DEVICE HAVING PROTECTED INTERIOR WALLS 1 2008
* 2009/0142,386 CONTROL OF DRUG RELEASE BY TRANSIENT MODIFICATION OF LOCAL MICROENVIRONMENTS 1 2009
* 2009/0234,214 MULTI-RESERVOIR DEVICE AND METHOD FOR TRANSDERMAL SENSING 2 2009
 
THE CURATORS OF THE UNIVERSITY OF MISSOURI (1)
8,703,216 Engineered comestible meat 1 2012
 
SUZUKI, MAMORU (2)
6,932,610 Process for producing an artificial bone model and an artificial bone model produced by the process 23 2003
* 2004/0175,686 Process for producing an artificial bone model and an artificial bone model produced by the process 2 2003
 
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (5)
9,255,178 Photocrosslinkable poly (caprolactone fumarate) 0 2005
7,718,109 Tissue support structure 13 2006
* 2006/0249,875 Tissue support structure 3 2006
8,912,247 Hydrophilic/hydrophobic polymer networks based on poly(caprolactone fumarate), poly(ethylene glycol fumarate), and copolymers thereof 0 2006
* 2008/0262,102 Hydrophilic/Hydrophobic Polymer Networks Based on Poly(Caprolactone Fumarate), Poly(Ethylene Glycol Fumarate), and Copolymers Thereof 2 2006
 
SPX FLOW, INC. (3)
6,796,770 Impeller and method using solid free form fabrication 4 2002
7,056,095 Impeller and method using solid free form fabrication 5 2004
* 2006/0110,256 IMPELLER AND METHOD USING SOLID FREE FORM FABRICATION 4 2004
 
Z CORPORATION (4)
* 2005/0059,757 Absorbent fillers for three-dimensional printing 15 2004
* 2006/0230,984 Three dimensional printing material system and method 14 2006
* 2007/0241,482 Production of three-dimensional objects by use of electromagnetic radiation 24 2007
* 2008/0252,682 Apparatus and Methods for Servicing 3D Printers 1 2008
 
THEKEN SPINE, LLC (8)
6,213,168 Apparatus and method for dispensing of powders 11 1999
6,454,811 Composites for tissue regeneration and methods of manufacture thereof 150 1999
6,341,952 Fabrication of tissue products with additives by casting or molding using a mold formed by solid free-form methods 15 2001
* 6,772,026 System and method for rapidly customizing design, manufacture and/or selection of biomedical devices 232 2001
* 2002/0059,049 System and method for rapidly customizing design, manufacture and/or selection of biomedical devices 174 2001
7,122,057 Method and apparatus for engineered regenerative biostructures such as hydroxyapatite substrates for bone healing applications 41 2002
* 2003/0065,400 Method and apparatus for engineered regenrative biostructures such as hydroxyapatite substrates for bone healing applications 16 2002
* 2007/0009,606 Manufacturing process, such as three dimensional printing, including binding of water-soluble material followed by softening and flowing and forming films of organic-solvent-soluble material 3 2005
 
ADAMS, ROBERT W. (1)
* 2015/0250,715 PROCESS FOR MAKING CONTROLLED RELEASE MEDICAL IMPLANT PRODUCTS 0 2013
 
WAKE FOREST UNIVERSITY HEALTH SCIENCES (5)
8,834,520 Devices and methods for treating spinal cord tissue 0 2008
9,289,193 Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage 0 2009
9,131,927 Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage 0 2009
* 8,764,794 Device and method for treating central nervous system pathology 0 2012
9,050,136 External fixation assembly and method of use 0 2013
 
BIOMET MANUFACTURING, LLC (2)
* 8,679,191 Continuous phase composite for musculoskeletal repair 0 2011
* 2011/0190,903 CONTINUOUS PHASE COMPOSITE FOR MUSCULOSKELETAL REPAIR 1 2011
 
BOSTON SCIENTIFIC SCIMED, INC. (6)
6,641,776 Method for preparing radiopaque surgical implement 7 2000
6,991,647 Bioresorbable stent 98 2001
7,041,130 Stent for controlled release of drug 98 2004
* 2004/0260,391 Stent for controlled release of drug 11 2004
* 2004/0247,671 Solid drug formulation and device for storage and controlled delivery thereof 72 2004
* 2007/0106,363 Medical devices having particle-containing regions with diamond-like coatings 27 2005
 
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (1)
* 2011/0129,924 Porous Polymeric Articles 1 2006
 
EXONE GMBH (18)
8,741,194 Method for producing a part using a depostion technique 5 2000
7,204,684 Interchangeable container 32 2001
7,004,222 Device for manufacturing models layer by layer 33 2001
7,879,393 Method and device for applying fluids 8 2002
7,531,117 Method for constructing patterns in a layered manner 5 2003
* 2004/0035,542 Device for manufacturing models layer by layer 13 2003
* 2004/0026,418 Interchangeable container 6 2003
* 2004/0170,765 Method and device for applying fluids 32 2004
7,807,077 Methods and systems for the manufacture of layered three-dimensional forms 3 2004
8,020,604 Method for the layered construction of models 2 2004
* 2005/0167,872 Method for constructing patterns in a layered manner 26 2005
7,137,431 Device for pattern building in layers 22 2005
* 2006/0108,090 Device for pattern building in layers 3 2005
8,506,870 Methods of manufacturing layered three-dimensional forms 1 2008
* 2008/0237,933 Methods and systems for manufacturing the manufacture of layered three-dimensional forms 7 2008
7,955,537 Method for constructing patterns in a layered manner 1 2009
8,122,939 Method for the layered construction of models 1 2011
9,403,324 Method for producing a part using a deposition technique 0 2014
 
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (1)
8,288,590 N-substituted monomers and polymers 0 2011
* Cited By Examiner