LHRH antagonists having modified aminoacyl residues at positions 5 and 6
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United States of America Patent
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Feb 13, 1996
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app pub date -
Jul 28, 1994
filing date -
Dec 18, 1992
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Abstract
A class of potent LHRH decapeptide antagonists possess N-alkylated aminoacyl residues where the side-chain portion of the residue is a 4-(substimtedamino)phenylalanyl, 4-(substituted-amino)cyclohexylalanyl, or .OMEGA.-(substitutedamino)alkyl group, and additionally the aminoacyl residues at position 5 are N-alkylated on the nitrogen atom of the peptide backbone.
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