Apparatus and methodology for determining oxygen in biological systems

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United States of America Patent

PATENT NO 5494030
SERIAL NO

08105459

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Abstract

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The invention provides apparatus and methods for measuring oxygen tensions in biological systems utilizing physiologically acceptable paramagnetic material, such as India ink or carbon black, and electron paramagnetic resonance (EPR) oximetry. India ink is introduced to the biological system and exposed to a magnetic field and an electromagnetic field in the 1-2 GHz range. The EPR spectra is then measured at the biological system to determine oxygen concentration. The EPR spectra is determined by an EPR spectrometer that adjusts the resonator to a single resonator frequency to compensate for movements of the biological system, such as a human or animal. The biological system can also include other in vivo tissues, cells, and cell cultures to directly measure pO.sub.2 non-destructively.

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Patent Owner(s)

  • TRUSTEES OF DARTMOUTH COLLEGE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Goda, Fuminori Hanover, NH 3 251
Liu, Ke J Hanover, NH 2 140
Swartz, Harold M Hanover, NH 9 281
Walczak, Tadeusz Hanover, NH 3 251

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