Propofol hydrofluorocarbon propellant formulations
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United States of America Patent
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Mar 5, 1996
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N/A
app pub date -
Mar 23, 1995
filing date -
Mar 23, 1995
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Abstract
Non-volatile general anesthetics are advantageously provided to patients in aerosolized form using a metered dose inhaler. The anesthetics are highly lipophilic in character and are rapidly absorbed through the nasal, oral, and lung mucosa. Experiments have shown that propofol is readily soluble in hydrofluorocarbon propellants without the use of surfactants and co-solvents. The solubility allows for the controlled delivery of concentrated pure anesthetic agents like propofol to the airway mucosa of human and animal patients to cause rapid onset of sedation or anesthesia without the requirement of prior intravenous access.
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