US Patent No: 5,497,764

Number of patents in Portfolio can not be more than 2000

Medication cassette for an automatic aerosol medication delivery

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Importance

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Abstract

A portable, battery powered, hand-held system for releasing a controlled dose of aerosol medication for inhalation by a patient including a durable body and a medication cassette inserted in the durable body. The cassette includes a housing for containing a canister of medication, bears an identification code, and permits the canister to be manually depressed to release a dose, e.g., a metered dose, when out of the durable body. The durable body includes an actuator mechanism for engaging an inserted cassette and its canister, and an actuator release mechanism for controlling the actuator mechanism to depress the canister for a selected period of time to release the desired dose of medication and then the release the canister. The actuator mechanism, includes a compression spring for depressing the canister and a torsion spring for reloading the compression spring. The torsion spring is reloaded by rotating the cassette from an open position for delivering aerosol to a closed position. The actuator release mechanism includes a motor and trigger pin assembly that controls the release of the compression spring and the torsion spring, and, hence, the time that the canister is depressed. The motor operates in response to sensed flow satisfying a selected delivery threshold. The durable body includes a flow sensor having an asymmetrical orifice that is calibrated, independent of the cassette, to convert the sensed pressure due to flow into a flow rate. The orifice is separately calibrated for an inhalation flow rate range and an exhalation flow rate range over a selected number of known flow rates. The sensed pressure value is corrected for transducer offset drift and converted to a flow rate using the calibration data and piecewise linear interpolation.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ARADIGM CORPORATIONHAYWARD, CA118

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ritson, Carl San Jose, CA 29 1501
Rubsamen, Reid M Oakland, CA 95 4686

Cited Art

Patent Info (Count) # Cites Year
 
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YAMAHA CORPORATION (3)
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KEY PHARMACEUTICALS, INC. (2)
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THE JOHNS HOPKINS UNIVERSITY (2)
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4,926,852 Medication delivery system phase one 141 1988
 
ACKRAD LABORATORIES, INC. (1)
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ADVANCED TECHNICAL PRODUCTS, INC. (1)
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AKTIEBOLAGET DRACO (1)
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ARADIGM CORPORATION (1)
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ERICH JAEGER GMBH (1)
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GLAXO GROUP LIMITED (1)
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HEALTHTECH SERVICES CORP. (1)
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JAMES E. COOKE (1)
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MARVEN, AL (1)
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MICRO CARE CORPORATION (1)
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MINNESOTA MINING AND MANUFACTURING COMPANY (1)
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PURITAN-BENNETT CORPORATION (1)
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R. J. REYNOLDS TOBACCO COMPANY (1)
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SCHERING CORPORATION (1)
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SIERRA BIOTECHNOLOGY COMPANY, L.C. (1)
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SVEN-ERIK NILSSON (1)
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Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
ORIEL THERAPEUTICS, INC. (8)
6,889,690 Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages 27 2003
7,677,411 Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders 0 2003
7,118,010 Apparatus, systems and related methods for dispensing and /or evaluating dry powders 11 2003
6,985,798 Dry powder dose filling systems and related methods 7 2003
7,451,761 Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances 7 2004
7,377,277 Blister packages with frames and associated methods of fabricating dry powder drug containment systems 2 2004
7,520,278 Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages 5 2005
7,428,446 Dry powder dose filling systems and related methods 2 2005
 
S.C. JOHNSON & SON, INC. (7)
7,837,065 Compact spray device 4 2005
D535004 Cover plate for a fragrance dispenser 34 2005
8,061,562 Compact spray device 1 2007
8,091,734 Compact spray device 0 2010
7,954,667 Compact spray device 1 2010
8,342,363 Compact spray device 0 2011
D679793 Dispenser shroud 0 2012
 
ARADIGM CORPORATION (5)
5,608,647 Method for releasing controlled amount of aerosol medication 126 1995
5,826,570 Delivery of aerosol medications for inspiration 35 1997
6,624,885 Method and device for non-destructive analysis of perforation in a material 4 1999
7,148,960 Method and device for non-destructive analysis of perforations in a material 2 2003
7,301,621 Method and device for non-destructive analysis of perforations in a material 0 2006
 
CLAVIUS DEVICES INC., A CORPORATION ORGANIZED UNDER THE LAWS OF THE STATE OF NEW YORK (4)
6,260,549 Breath-activated metered-dose inhaler 42 1998
6,425,392 Breath-activated metered-dose inhaler 43 1999
6,325,062 Breath-activated metered-dose inhaler 10 1999
6,318,361 Breath-activated metered-dose inhaler 39 1999
 
APTAR FRANCE SAS (2)
5,692,492 Hand-held inhalation-actuated spray device 94 1995
6,116,238 Dry powder inhaler 51 1997
 
CANON KABUSHIKI KAISHA (2)
7,779,835 Liquid ejection device 0 2007
8,240,303 Liquid ejection device 0 2010
 
SMITHKLINE BEECHAM CORPORATION (2)
6,990,975 Medicament delivery system 5 2000
7,322,355 Medicament dispenser 2 2000
 
ZHEJIANG HISUN PHARMACEUTICAL CO. LTD (2)
6,672,304 Inhalation actuated device for use with metered dose inhalers (MDIs) 15 2000
6,729,324 Inhalation actuated device for use with metered dose inhalers (MDIs) 5 2002
 
AGRAMEX CONSULTANTS LIMITED (1)
6,223,744 Wearable aerosol delivery apparatus 65 1999
 
BATTELLE MEMORIAL INSTITUTE (1)
7,607,435 Gas or liquid flow sensor 2 2004
 
GLAXO GROUP LIMITED (1)
6,981,499 Medicament dispenser 30 2000
 
INNOVATIVE DEVICES, A NORTH CAROLINA CORP. (1)
6,357,442 Inhalation actuated device for use with metered dose inhalers (MDIS) 10 1998
 
MEDI-STREAM PTY LTD ACN 111 815 715 (1)
7,686,016 Medication holder 3 2004
 
MICRODRUG AG (1)
6,089,227 Device for an inhaler 32 1997
 
NOVARTIS AG (1)
7,905,230 Metered dose inhaler with lockout 1 2003
 
SCHERING CORPORATION (1)
6,651,844 Spray dispenser counter 1 2002