Protein protease inhibitors from streptomyces

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United States of America Patent

PATENT NO 5498529
SERIAL NO

08162506

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Abstract

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This invention relates to a process for producing a heterologous polypeptide in Streptomyces which involves transforming a Streptomyces organism with a recombinant DNA molecule comprising an LEP-10 of LTl sequence selected from the group consisting of a sequence encoding a gene expression unit, a promoter sequence or an export control encoding sequence each operatively linked to a heterologous coding sequence and then culturing the transformed Streptomyces such that the heterologous polypeptide is expressed.

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Patent Owner(s)

Patent OwnerAddress
GLAXOSMITHKLINE LLC251 LITTLE FALLS DRIVE WILMINGTON DE 19808

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Berka, Thomas R Wyncote, PA 3 9
Fornwald, James A Norristown, PA 12 24
Gorniak, Joselina G Willow Grove, PA 2 2
Rosenberg, Martin Royersford, PA 78 220
Strickler, James E Havertown, PA 10 269
Taylor, Dean P King of Prussia, PA 9 17

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