Platelet aggregation-inhibiting peptides
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United States of America Patent
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Mar 12, 1996
Grant Date -
N/A
app pub date -
May 6, 1994
filing date -
Sep 7, 1992
priority date (Note) -
Expired
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Abstract
Novel peptide derivatives having RGD as a basic structure were found which have a platelet aggregation-inhibiting action, blood coagulation-inhibiting action and cell adhesion-inhibiting action. Utlizing these effects of the peptide derivatives, the following agents which comprise the peptides as active ingredients were provided: platelet aggregation-inhibiting agents that are effective in thrombolus during and after the treatment of thrombolysis and thromboembolism and that can further prevent reobstruction and cardiac infarction; blood coagulation-inhibiting agents that can inhibit blood coagulation which is the main cause of thrombus formation during extracorporeal circulation; cell adhesion-inhibiting agents; tumor metastasis-inhibiting agents; and agents for protecting platelet preparations for blood transfusion. In addition, the present invention intends to provide platelet preparation packs for blood transfusion, characterized in that the peptide dervatives are contained in platelet preparations for blood transfusion in packs.
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