Method for preparing cephalosporin derivatives
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United States of America Patent
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Mar 12, 1996
Grant Date -
N/A
app pub date -
Apr 20, 1994
filing date -
Apr 20, 1994
priority date (Note) -
Expired
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Abstract
A method for preparing cephalosporm derivatives by reacting cephalosporin alkaline metal salts with organic halide in the presence of quaternary ammonium salts catalyst is disclosed. .DELTA..sup.3 .fwdarw..DELTA..sup.2 isomerization, a side reaction commonly reported in preparation of cephalosporin derivatives was successfully eliminated. The desired .DELTA..sup.3 was obtained as a sole product in the reaction.
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