Amidic derivatives of glutamic, aspartic and 2-amino adipic acids, a process for preparing same, and anti-gastrin composition containing the derivatives
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United States of America Patent
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Mar 19, 1996
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N/A
app pub date -
Jun 10, 1993
filing date -
Dec 11, 1990
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Expired
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Abstract
Amidic derivatives of glutamic, aspartic and 2-amino adipic acids represented by the following formula (I): ##STR1## wherein r is from 1 to 3, R.sub.1 is an aryl group or a substituted aryl group, R.sub.2 is a 8-azaspiro(4.5)decan-8-yl group or a 3-azaspiro(5.5)decan-3-yl group, wherein said compound has a chiral center marked with an asterisk in said formula (I), thus forming a racemic (R,S) form or an isomeric form. The amidic derivatives are useful in treating ulcers, hypergastrinaemia-activated tumors, pathological conditions of CNS, biliary dyskinesia, colitis, pancreatistis, and surgically induced myosis.
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