N-terminus modified analogs of LHRH
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United States of America Patent
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Mar 26, 1996
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N/A
app pub date -
Jul 27, 1994
filing date -
Aug 6, 1993
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Abstract
Decapaptide and undecapaptides substituted on the N-terminal nitrogen atom by acyl groups which include furo-2-yl, isonicotinyl, nicotinyl, 2-, 3-, and 4-quinolinecarbonyl, shikimyl, dihydroshikimyl, and tetrahydrofur-2-oyl are potent antagonists of LHRH and are useful for suppressing the levels of sex hormones in mammals.
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