CDR grafted humanised chimeric T-cell antibodies

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United States of America Patent

PATENT NO 5502167
SERIAL NO

08244626

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A humanised antibody is provided in which the amino acid sequence of the CDRs is derived from the sequence of CDRs of a monoclonal antibody having the specificity of binding to resting and activated T-cells, inhibiting T-cell proliferation and lysing T-cells from mice transgenic for human CD2 and in which sufficient of the amino acid sequence of each CDR has been retained to provide the same specificity for the humanised antibody.

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Patent Owner(s)

  • THE TOLERX, INC. LIQUIDATING TRUST

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Crowe, James S the Wellcome Foundation Limited, Langley Court, South Eden Park Road, Beckenham, Kent, BR3 3BS, GB3 5 151
Lewis, Alan P the Wellcome Foundation Limited, Langley Court, South Eden Park Road, Beckenham, Kent, BR3 3BS, GB3 4 130
Waldmann, Herman University of Cambridge, Department of Pathology, Immunology Div., Tennis, Cambridge, CB2 1QP, GB3 47 1104
Walsh, Louise The University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge, CB2 1QP, GB3 3 147

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