CDR grafted humanised chimeric T-cell antibodies
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United States of America Patent
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Mar 26, 1996
Grant Date -
N/A
app pub date -
Jul 15, 1994
filing date -
Dec 6, 1991
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Abstract
A humanised antibody is provided in which the amino acid sequence of the CDRs is derived from the sequence of CDRs of a monoclonal antibody having the specificity of binding to resting and activated T-cells, inhibiting T-cell proliferation and lysing T-cells from mice transgenic for human CD2 and in which sufficient of the amino acid sequence of each CDR has been retained to provide the same specificity for the humanised antibody.
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- 15 United States
- 10 France
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- 5 Korea
- 2 Other
Patent Owner(s)
- THE TOLERX, INC. LIQUIDATING TRUST
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Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Crowe, James S | the Wellcome Foundation Limited, Langley Court, South Eden Park Road, Beckenham, Kent, BR3 3BS, GB3 | 5 | 151 |
Lewis, Alan P | the Wellcome Foundation Limited, Langley Court, South Eden Park Road, Beckenham, Kent, BR3 3BS, GB3 | 4 | 130 |
Waldmann, Herman | University of Cambridge, Department of Pathology, Immunology Div., Tennis, Cambridge, CB2 1QP, GB3 | 47 | 1104 |
Walsh, Louise | The University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge, CB2 1QP, GB3 | 3 | 147 |
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