Hybrid plasminogen activator
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United States of America Patent
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Apr 2, 1996
Issued Date -
N/A
app pub date -
Jun 6, 1994
filing date -
Nov 25, 1987
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Abstract
Hybrid proteins comprising a cross-linking domain derived from a protein that acts as an acyl-donor substrate for factor XIIIa, a fibrin-binding domain, and a serine protease domain are disclosed. Host cells transfected or transformed with an expression vector comprising a transcriptional promoter operably linked to a DNA sequence encoding such hybrid proteins are also disclosed, as well as methods for producing the proteins. The proteins may be utilized in combination with a suitable carrier or diluent as pharmaceutical compositions.
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