Stabilized pharmaceutical composition and stabilizing solvent
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United States of America Patent
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Apr 2, 1996
Issued Date -
N/A
app pub date -
Jan 18, 1995
filing date -
Sep 29, 1993
priority date (Note) -
Expired
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Abstract
A stabilized pharmaceutical composition containing paclitaxel, teniposide, camptothecin or other antineoplastic agent susceptible to degradation during storage is produced using a solvent system containing a low carboxylate anion content. The solvent system is a mixture of ethanol and a polyoxyethylated castor oil. The polyoxyethylated castor oil is treated with an acid or contacted with alumina to reduce the carboxylate anion content of the solvent. The low carboxylate anion content of the solvent provides extended shelf life and lower amounts of degradation by-products.
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