DNA encoding variant CD44 surface proteins associated with metastatic tumors

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United States of America Patent

PATENT NO 5506119
SERIAL NO

07946497

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The presence of certain extracellular regions ('ECR') from human and rat variants of the CD44 membrane glycoprotein have been found to be associated with metastasis ability in tumor cells. Isolated polynucleotides encoding the ECRs permit expression of the ECR polypeptide, which in turn can be used as an antigen to obtain monoclonal antibodies that recognize the ECR polypeptide. The anti-ECR monoclonal antibodies have the ability to prevent metastasis by tumor cells that would otherwise metastasize and spread.

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Patent Owner(s)

  • DEUTSCHES KREBSFORSCHUNGSZENTRUM;FORSCHUNGSZENTRUM KARLSRUHE GMBH;UNIVERSITAT KARLSRUHE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Guenthert, Ursula Basel, CH 3 7
Herrlich, Peter Karlsruhe, DE 14 44
Matzku, Siegfried Wiesenbach, DE 9 132
Ponta, Helmut Linkenheim, DE 17 43
Wenzel, Achim Heidelberg, DE 3 7

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