Prenatal screening for down's syndrome
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United States of America Patent
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Apr 9, 1996
Issued Date -
N/A
app pub date -
Jul 7, 1992
filing date -
Jul 9, 1987
priority date (Note) -
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Abstract
A prenatal screening test for risk of Down's Syndrome in a foetus, which is carried out on a maternal blood sample before the beginning of the third trimester of pregnancy, by assaying the sample for a metabolite of feto-placental activity which is affected by the presence of Down's Syndrome, selected from unconjugated oestriol; progesterone; 16-alpha-hydroxy-dehydroepiandrosterone sulphate (16-alpha-hydroxy-DHEAS); and dehydroepiandrosterone sulphate (DHEAS). An additional assay for alpha-fetroprotein and/or human chorionic gonadotrophin may be included.
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