US Patent No: 5,509,404

Number of patents in Portfolio can not be more than 2000

Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values

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Abstract

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A method of drug delivery is disclosed wherein a patient's inspiratory flow rate and inspiratory volume are simultaneously measured using a portable, hand-held, device which may be electronic and battery-powered or mechanical. Information obtained from the measurement is used to release, into a patient's inspiratory flow path, particles of a pharmaceutically active drug. The released particles have a particle size in the range of from about 0.5 to 12 microns. The drug is released when the patient's measured inspiratory flow rate is in the range of from about 0.10 to about 2.0 liters/second and the patient's inspiratory volume is in the range of from about 0.15 to about 0.8 liters. By measuring inspiratory flow and volume and releasing within the specific parameters with respect to both flow and volume, it is possible to obtain a high degree of repeatability with respect to dosing of a patient and further to deliver a relatively high percentage of the released drug to the patient's circulatory system.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ARADIGM CORPORATIONHAYWARD, CA61

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lloyd, Lester J Orinda, CA 15 1677
Rubsamen, Reid M Oakland, CA 108 5556

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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MOULDING, THOMAS S., JR. (1)
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YAMAHA CORPORATION (1)
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LANPHER DIAGNOSTIC WORKSTATIONS, INC. (1)
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BESPAK PLC (1)
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UNIVERSITY OF AUCKLAND (1)
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ACKRAD LABORATORIES, INC. (1)
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Key Pharmaceuticals, Inc. (1)
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SIERRA BIOTECHNOLOGY COMPANY, L.C. (1)
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* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
PROTEUS DIGITAL HEALTH, INC. (2)
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6,494,207 Harness assembly for a nasal mask 77 1997
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6,119,693 Forehead support for facial mask 255 1998
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6,561,190 Mask and a vent assembly therefor 106 1998
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7,036,508 Harness assembly for a nasal mask 26 2002
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6,997,188 Forehead support for facial mask 9 2003
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7,320,320 Determination of patency of the airway 3 2003
D550351 Elastic gas washout vent for a respiratory mask 2 2004
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7,503,327 Mask with integral cushion and forehead piece 24 2004
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7,644,713 Method and apparatus for determining instantaneous leak during ventilatory assistance 24 2006
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7,610,916 Forehead support for facial mask 13 2006
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8,636,006 Mask 0 2007
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7,762,259 Mask with integral cushion and forehead piece 17 2007
8,517,023 Mask system with interchangeable headgear connectors 1 2008
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8,550,084 Mask system 3 2009
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8,051,853 Method and apparatus for providing ventilatory assistance 9 2009
8,505,535 Mask system 2 2009
8,360,060 Distinguishing between closed and open airway apneas and treating patients accordingly 0 2010
8,210,180 Mask with integral cushion and forehead piece 32 2010
8,381,722 Distinguishing between closed and open airway apneas and treating patients accordingly 1 2010
8,757,162 Nasal assembly 3 2010
8,833,371 Mask and vent assembly therefor 0 2010
8,528,558 Respiratory mask having washout vent and gas washout vent assembly for a respiratory mask 0 2011
8,353,294 Respiratory mask assembly 6 2011
8,646,450 Forehead support for a facial mask 0 2011
8,522,783 Cushion and mask therefor 1 2011
8,733,351 Method and apparatus for providing ventilatory assistance 0 2011
8,813,748 Full-face mask and mask cushion therefor 0 2011
8,684,000 Administration of CPAP treatment pressure in presence of apnea 0 2012
8,794,239 Mask with integral cushion and forehead piece 0 2012
8,485,192 Cushion for patient interface 1 2012
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8,613,281 Cushion for patient interface 0 2012
8,578,935 Cushion for patient interface 0 2012
8,573,215 Cushion for patient interface 0 2012
8,555,885 Cushion for patient interface 0 2012
8,550,081 Cushion for patient interface 0 2012
8,550,082 Cushion for patient interface 0 2012
8,550,083 Cushion for patient interface 0 2012
8,752,547 Distinguishing between closed and open airway apneas and treating patients accordingly 0 2012
8,528,561 Mask system 2 2013
8,522,784 Mask system 10 2013
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8,944,061 Cushion to frame assembly mechanism 0 2013
8,960,196 Mask system with interchangeable headgear connectors 0 2013
 
MEDTRONIC, INC. (1)
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INVACARE CORPORATION (5)
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7,621,274 Nasal mask 36 2003
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D583931 Nasal mask 0 2004
8,028,698 Breathing mask 0 2007
 
PROFILE RESPIRATORY SYSTEMS LIMITED (1)
8,967,140 Controlling drug delivery apparatus 0 2001
 
VERMEER MANUFACTURING COMPANY (1)
6,740,046 Method and apparatus for enhancing patient compliance during inspiration measurements 17 2002
 
CLAVIUS DEVICES INC., A CORPORATION ORGANIZED UNDER THE LAWS OF THE STATE OF NEW YORK (4)
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BATTELLE MEMORIAL INSTITUTE (1)
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RESPIRONICS (UK) LTD. (1)
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ASTRAZENECA AB (1)
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8,746,250 Breathing mask for feeding a breathing gas to a mask user and discharge device for discharging breathing gas 1 2013
 
ASTRA AKTIEBOLAG (2)
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6,686,346 Formulation 20 2001
 
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PHILIP MORRIS USA INC. (1)
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SYDNEY SOUTH WEST AREA HEALTH SERVICE (1)
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HILL-ROM SERVICES PTE. LTD (1)
8,251,876 Breathing exercise apparatus 0 2008
 
GLAXO GROUP LIMITED (1)
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RESMED R&D GERMANY GMBH (8)
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8,371,301 Breathing mask for feeding a breathing gas to a mask user and discharge device for discharging breathing gas 3 2010
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8,479,738 Breathing mask arrangement as well as an application device and a forehead support device for same 2 2011
 
ARADIGM CORPORATION (21)
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6,408,854 Insulin delivery enhanced by coached breathing 27 2000
6,250,298 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 38 2000
6,431,166 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 21 2001
6,427,681 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 5 2001
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7,490,603 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 1 2005
* Cited By Examiner