US Patent No: 5,509,404

Number of patents in Portfolio can not be more than 2000

Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A method of drug delivery is disclosed wherein a patient's inspiratory flow rate and inspiratory volume are simultaneously measured using a portable, hand-held, device which may be electronic and battery-powered or mechanical. Information obtained from the measurement is used to release, into a patient's inspiratory flow path, particles of a pharmaceutically active drug. The released particles have a particle size in the range of from about 0.5 to 12 microns. The drug is released when the patient's measured inspiratory flow rate is in the range of from about 0.10 to about 2.0 liters/second and the patient's inspiratory volume is in the range of from about 0.15 to about 0.8 liters. By measuring inspiratory flow and volume and releasing within the specific parameters with respect to both flow and volume, it is possible to obtain a high degree of repeatability with respect to dosing of a patient and further to deliver a relatively high percentage of the released drug to the patient's circulatory system.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ARADIGM CORPORATIONHAYWARD, CA62

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lloyd, Lester J Orinda, CA 15 1655
Rubsamen, Reid M Oakland, CA 108 5442

Cited Art Landscape

Patent Info (Count) # Cites Year
 
The Johns Hopkins University (2)
* 4,790,305 Medication delivery system 155 1986
* 4,926,852 Medication delivery system phase one 152 1988
 
ACKRAD LABORATORIES, INC. (1)
* 4,648,393 Breath activated medication spray 96 1984
 
BESPAK PLC (1)
* 4,896,832 Dispensing apparatus for metered quantities of pressurised fluid 87 1988
 
Key Pharmaceuticals, Inc. (1)
* 4,484,577 Drug delivery method and inhalation device therefor 159 1982
 
LANPHER DIAGNOSTIC WORKSTATIONS, INC. (1)
* 5,363,842 Intelligent inhaler providing feedback to both patient and medical professional 313 1991
 
MOULDING, THOMAS S., JR. (1)
* 4,604,847 Medicine package, method of opening the package, and machine for performing the method 117 1983
 
SIERRA BIOTECHNOLOGY COMPANY, L.C. (1)
* 4,984,158 Metered dose inhaler biofeedback training and evaluation system 285 1988
 
UNIVERSITY OF AUCKLAND (1)
* 4,677,975 Method of dispensing and/or a dispenser 344 1985
 
YAMAHA CORPORATION (1)
* 2003/0023,649 Digital filtering method and device and sound image localizing device 4 2002
 
Other [Check patent profile for assignment information] (3)
* 4,592,348 Aerosol inhaler 58 1984
* 4,803,978 Apparatus for actuating an inhaler 47 1987
* 4,852,582 Method and kit for measuring the effectiveness of bronchodilators 40 1987
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
RESMED LIMITED (111)
6,123,071 Facial masks for assisted respiration or CPAP 117 1996
6,112,746 Nasal mask and mask cushion therefor 260 1997
6,240,921 Automated stop/start control in the administration of CPAP treatment 26 1997
6,253,764 Control of delivery pressure in CPAP treatment or assisted respiration 26 1997
6,152,129 Determination of leak and respiratory airflow 82 1997
D428987 Nasal mask shell 53 1997
D423096 Nasal mask cushion 62 1997
6,138,675 Determination of the occurrence of an apnea 70 1997
6,532,957 Assisted ventilation to match patient respiratory need 59 1997
6,123,082 Device for preventing or reducing the passage of air through the mouth 51 1997
6,029,665 Determination of patency of airway 59 1997
6,332,463 Flow estimation and compensation of flow-induced pressure swings in CPAP treatment and assisted respiration 42 1997
6,494,207 Harness assembly for a nasal mask 74 1997
6,044,844 Mask and harness assembly 154 1997
6,213,119 Inspiratory duration in CPAP or assisted respiration treatment 68 1997
6,029,660 Substance delivery apparatus 69 1997
6,091,973 Monitoring the occurrence of apneic and hypopneic arousals 114 1997
6,119,693 Forehead support for facial mask 249 1998
6,367,474 Administration of CPAP treatment pressure in presence of APNEA 64 1998
6,237,592 Auto-calibration of pressure transducer offset 25 1998
6,561,190 Mask and a vent assembly therefor 97 1998
6,119,723 Apparatus for varying the flow area of a conduit 9 1998
6,237,593 Estimation of flow and detection of breathing CPAP treatment 15 1998
6,182,657 Pressure control in CPAP treatment or assisted respiration 15 1998
D421298 Flow generator 71 1998
6,336,454 Nasal ventilation as a treatment for stroke 13 1998
6,397,841 Apparatus for supplying breathable gas 44 1998
6,216,691 Mounting body 20 1998
6,513,526 Full-face mask and mask cushion therefor 126 1999
6,357,441 Nasal mask and mask cushion therefor 163 1999
6,561,191 Mask and a vent assembly therefor 46 1999
6,363,270 Monitoring the occurrence of apneic and hypopneic arousals 84 1999
6,279,569 Determination of leak and respiratory airflow 35 2000
6,634,358 Nasal mask cushion assembly 59 2000
6,463,931 Forehead support for facial mask 78 2000
6,526,974 Pressure control in CPAP treatment or assisted respiration 12 2000
6,776,155 Nasal ventilation as a treatment for stroke 5 2001
6,871,649 Nasal mask cushion assembly 30 2001
6,581,602 Nasal mask and mask cushion therefor 95 2002
7,178,527 Nasal mask and mask cushion therefor 12 2002
6,688,307 Methods and apparatus for determining instantaneous elastic recoil and assistance pressure during ventilatory support 34 2002
7,036,508 Harness assembly for a nasal mask 25 2002
6,557,556 Forehead support for facial mask 37 2002
6,701,927 Full-face mask and mask cushion therefor 83 2002
6,810,876 Assisted ventilation to match patient respiratory need 62 2002
6,691,708 Forehead support for facial mask 64 2002
6,860,269 Forehead support for facial mask 64 2002
7,845,354 Mask and vent assembly therefor 5 2002
6,973,929 Forehead support for a facial mask 13 2002
D498529 Portion of a cushion for use with a mask assembly in the application of continuous positive airway pressure (CPAP) 6 2003
7,207,335 Mask and vent assembly therefor 26 2003
7,302,950 Patient interface for respiratory apparatus 35 2003
8,522,785 Inextensible headgear and CPAP or ventilator mask assembly with the same 0 2003
6,997,188 Forehead support for facial mask 9 2003
7,234,466 Forehead support for facial mask 16 2003
7,069,933 Breathing mask and mask cushion therefor 11 2003
7,320,320 Determination of patency of the airway 3 2003
D550351 Elastic gas washout vent for a respiratory mask 2 2004
7,137,389 Method and apparatus for determining instantaneous inspired volume of a subject during ventilatory assistance 29 2004
7,503,327 Mask with integral cushion and forehead piece 21 2004
7,406,965 Forehead support for facial mask 8 2004
7,243,651 Cushion and mask therefor 7 2004
7,942,150 Nasal assembly 15 2005
7,882,837 Forehead support for facial mask 6 2005
7,644,713 Method and apparatus for determining instantaneous leak during ventilatory assistance 22 2006
7,926,487 Respiratory mask having gas washout vent and gas washout vent assembly for a respiratory mask 9 2006
8,056,561 Full-face mask and mask cushion therefor 1 2006
7,610,916 Forehead support for facial mask 12 2006
8,122,886 Respiratory mask assembly with vent 0 2006
8,636,006 Mask 0 2007
7,931,023 Patient interface assembly for CPAP respiratory apparatus 10 2007
7,950,392 Cushion and mask therefor 1 2007
7,730,886 Determination of patency of the airway 0 2007
7,762,259 Mask with integral cushion and forehead piece 14 2007
8,517,023 Mask system with interchangeable headgear connectors 1 2008
8,869,797 Cushion and cushion to frame assembly mechanism for patient interface 0 2008
7,942,149 Forehead support for a facial mask 7 2009
8,550,084 Mask system 2 2009
8,186,348 Forehead support for facial mask 7 2009
8,051,853 Method and apparatus for providing ventilatory assistance 7 2009
8,505,535 Mask system 2 2009
8,360,060 Distinguishing between closed and open airway apneas and treating patients accordingly 0 2010
8,210,180 Mask with integral cushion and forehead piece 29 2010
8,381,722 Distinguishing between closed and open airway apneas and treating patients accordingly 1 2010
8,757,162 Nasal assembly 3 2010
8,833,371 Mask and vent assembly therefor 0 2010
8,528,558 Respiratory mask having washout vent and gas washout vent assembly for a respiratory mask 0 2011
8,353,294 Respiratory mask assembly 4 2011
8,646,450 Forehead support for a facial mask 0 2011
8,522,783 Cushion and mask therefor 1 2011
8,733,351 Method and apparatus for providing ventilatory assistance 0 2011
8,813,748 Full-face mask and mask cushion therefor 0 2011
8,684,000 Administration of CPAP treatment pressure in presence of apnea 0 2012
8,794,239 Mask with integral cushion and forehead piece 0 2012
8,485,192 Cushion for patient interface 1 2012
8,613,280 Cushion for patient interface 0 2012
8,573,213 Cushion for patient interface 0 2012
8,567,404 Cushion for patient interface 0 2012
8,573,214 Cushion for patient interface 1 2012
8,616,211 Cushion for patient interface 0 2012
8,613,281 Cushion for patient interface 0 2012
8,578,935 Cushion for patient interface 0 2012
8,573,215 Cushion for patient interface 0 2012
8,555,885 Cushion for patient interface 0 2012
8,550,081 Cushion for patient interface 0 2012
8,550,082 Cushion for patient interface 0 2012
8,550,083 Cushion for patient interface 0 2012
8,752,547 Distinguishing between closed and open airway apneas and treating patients accordingly 0 2012
8,528,561 Mask system 2 2013
8,522,784 Mask system 8 2013
8,826,910 Mask and vent assembly therefor 0 2013
 
ARADIGM CORPORATION (21)
* 5,915,378 Creating an aerosolized formulation of insulin 135 1995
* 5,888,477 Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin 37 1997
* 5,855,564 Aerosol extrusion mechanism 35 1997
* 6,131,567 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 43 1998
* 6,085,753 Insulin delivery enhanced by coached breathing 37 1998
* 6,098,615 Method of reproducibly effecting a patient's glucose level 37 1998
* 5,970,973 Method of delivering insulin lispro 51 1998
* 5,873,358 Method of maintaining a diabetic patient's blood glucose level in a desired range 16 1998
* 6,024,090 Method of treating a diabetic patient by aerosolized administration of insulin lispro 16 1998
* 5,971,951 Aerosol extrusion mechanism 43 1998
6,408,854 Insulin delivery enhanced by coached breathing 25 2000
6,250,298 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 38 2000
6,431,166 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 20 2001
6,427,681 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 5 2001
6,431,167 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 9 2001
6,830,744 Compositions methods and systems for pulmonary delivery of recombinant human interferon alpha-2b 0 2002
6,647,987 Insulin delivery enhanced by coached breathing 3 2002
7,021,309 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 3 2003
7,278,419 Method for treating diabetes mellitus in a patient 5 2004
7,448,375 Method of treating diabetes mellitus in a patient 5 2005
7,490,603 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 1 2005
 
ORIEL THERAPEUTICS, INC. (8)
6,889,690 Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages 49 2003
7,677,411 Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders 0 2003
7,118,010 Apparatus, systems and related methods for dispensing and /or evaluating dry powders 16 2003
6,985,798 Dry powder dose filling systems and related methods 12 2003
7,451,761 Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances 21 2004
7,377,277 Blister packages with frames and associated methods of fabricating dry powder drug containment systems 7 2004
7,520,278 Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages 11 2005
7,428,446 Dry powder dose filling systems and related methods 2 2005
 
RESMED R&D GERMANY GMBH (8)
7,100,610 Breathing mask for feeding a breathing gas to a mask user and discharge device for discharging breathing gas 30 2001
7,000,614 Breathing mask arrangement and a forehead support device for same 46 2002
7,320,323 Breathing mask device and application device and frontal support device thereof 21 2002
7,967,014 Application device for breathing mask arrangement 9 2006
8,402,972 Breathing mask arrangement and a forehead support device for same 2 2009
8,371,301 Breathing mask for feeding a breathing gas to a mask user and discharge device for discharging breathing gas 2 2010
8,875,710 Application device for a breathing mask arrangement 0 2011
8,479,738 Breathing mask arrangement as well as an application device and a forehead support device for same 1 2011
 
INVACARE CORPORATION (5)
7,290,546 Nasal mask 16 2003
7,621,274 Nasal mask 34 2003
D507831 Nasal mask 7 2004
D583931 Nasal mask 0 2004
8,028,698 Breathing mask 0 2007
 
BOSTON MEDICAL TECHNOLOGIES, INC. (4)
* 6,106,481 Method and apparatus for enhancing patient compliance during inspiration measurements 32 1997
* 5,984,954 Methods and apparatus for R-wave detection 6 1997
* 6,161,037 Methods and apparatus for R-wave detection 12 1999
6,436,053 Method and apparatus for enhancing patient compliance during inspiration measurements 16 2000
 
CLAVIUS DEVICES INC., A CORPORATION ORGANIZED UNDER THE LAWS OF THE STATE OF NEW YORK (4)
6,260,549 Breath-activated metered-dose inhaler 55 1998
6,425,392 Breath-activated metered-dose inhaler 55 1999
6,325,062 Breath-activated metered-dose inhaler 14 1999
6,318,361 Breath-activated metered-dose inhaler 44 1999
 
NOVARTIS PHARMA AG (3)
6,655,379 Aerosolized active agent delivery 38 1999
6,606,992 Systems and methods for aerosolizing pharmaceutical formulations 37 2000
7,185,651 Flow regulator for aerosol drug delivery and methods 4 2003
 
ASTRA AKTIEBOLAG (2)
* 6,291,445 Low dose budesonide formulations and uses thereof 10 1997
6,686,346 Formulation 19 2001
 
MAP MEDIZIN-TECHNOLOGIE GMBH (2)
7,654,263 Breathing mask arrangement and a forehead support device for same 15 2005
7,992,559 Breathing mask arrangement as well as an application device and a forehead support device for same 13 2007
 
MAP-MEDIZINTECHNOLOGIE GMBH (2)
7,775,209 Breathing mask for feeding a breathing gas to a mask user and discharge device for discharging breathing gas 26 2006
8,746,250 Breathing mask for feeding a breathing gas to a mask user and discharge device for discharging breathing gas 0 2013
 
PROTEUS DIGITAL HEALTH, INC. (2)
8,419,638 Body-associated fluid transport structure evaluation devices 0 2008
8,332,020 Two-wrist data gathering system 0 2011
 
ASTRAZENECA AB (1)
6,986,904 Formulation 5 2003
 
BATTELLE MEMORIAL INSTITUTE (1)
7,607,435 Gas or liquid flow sensor 6 2004
 
CANON KABUSHIKI KAISHA (1)
8,333,188 Medicine ejection apparatus and control method thereof 0 2009
 
CAREFUSION 205, INC. (1)
7,007,696 Mask cushion and method of using same 50 2002
 
GLAXO GROUP LIMITED (1)
* 5,795,594 Salmeterol xinafoate with controlled particle size 49 1996
 
HILL-ROM SERVICES PTE. LTD (1)
8,251,876 Breathing exercise apparatus 0 2008
 
MEDTRONIC, INC. (1)
* 6,928,338 Decision information system for drug delivery devices 32 2002
 
PHILIP MORRIS USA INC. (1)
* 7,128,067 Method and apparatus for generating an aerosol 12 2003
 
RESPIRONICS (UK) LTD. (1)
* 7,451,760 Controlling drug delivery apparatus 1 2001
 
SYDNEY SOUTH WEST AREA HEALTH SERVICE (1)
* 5,817,028 Method and device for the provocation of air passage narrowing and/or the induction of sputum 42 1996
 
VERMEER MANUFACTURING COMPANY (1)
6,740,046 Method and apparatus for enhancing patient compliance during inspiration measurements 16 2002
 
Other [Check patent profile for assignment information] (1)
8,844,537 System and method for alleviating sleep apnea 0 2010
* Cited By Examiner