US Patent No: 5,509,404

Number of patents in Portfolio can not be more than 2000

Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values

1 Status Updates

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

A method of drug delivery is disclosed wherein a patient's inspiratory flow rate and inspiratory volume are simultaneously measured using a portable, hand-held, device which may be electronic and battery-powered or mechanical. Information obtained from the measurement is used to release, into a patient's inspiratory flow path, particles of a pharmaceutically active drug. The released particles have a particle size in the range of from about 0.5 to 12 microns. The drug is released when the patient's measured inspiratory flow rate is in the range of from about 0.10 to about 2.0 liters/second and the patient's inspiratory volume is in the range of from about 0.15 to about 0.8 liters. By measuring inspiratory flow and volume and releasing within the specific parameters with respect to both flow and volume, it is possible to obtain a high degree of repeatability with respect to dosing of a patient and further to deliver a relatively high percentage of the released drug to the patient's circulatory system.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
ARADIGM CORPORATIONHAYWARD, CA60

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lloyd, Lester J Orinda, CA 15 1728
Rubsamen, Reid M Berkeley, CA 96 5733

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (3)
* 4,592,348 Aerosol inhaler 62 1984
* 4,803,978 Apparatus for actuating an inhaler 49 1987
* 4,852,582 Method and kit for measuring the effectiveness of bronchodilators 44 1987
 
MOULDING, THOMAS S., JR. (1)
* 4,604,847 Medicine package, method of opening the package, and machine for performing the method 120 1983
 
YAMAHA CORPORATION (1)
* 2003/0023,649 Digital filtering method and device and sound image localizing device 4 2002
 
LANPHER DIAGNOSTIC WORKSTATIONS, INC. (1)
* 5,363,842 Intelligent inhaler providing feedback to both patient and medical professional 343 1991
 
THE JOHNS HOPKINS UNIVERSITY (2)
* 4,790,305 Medication delivery system 167 1986
* 4,926,852 Medication delivery system phase one 158 1988
 
BESPAK PLC (1)
* 4,896,832 Dispensing apparatus for metered quantities of pressurised fluid 96 1988
 
UNIVERSITY OF AUCKLAND (1)
* 4,677,975 Method of dispensing and/or a dispenser 357 1985
 
ACKRAD LABORATORIES, INC. (1)
* 4,648,393 Breath activated medication spray 98 1984
 
Key Pharmaceuticals, Inc. (1)
* 4,484,577 Drug delivery method and inhalation device therefor 168 1982
 
SIERRA BIOTECHNOLOGY COMPANY, L.C. (1)
* 4,984,158 Metered dose inhaler biofeedback training and evaluation system 299 1988
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
PROTEUS DIGITAL HEALTH, INC. (5)
8,419,638 Body-associated fluid transport structure evaluation devices 0 2008
9,084,566 Smart parenteral administration system 0 2009
9,014,779 Data gathering system 0 2011
8,332,020 Two-wrist data gathering system 2 2011
9,008,761 Two-wrist data gathering system 0 2012
 
Other [Check patent profile for assignment information] (2)
8,844,537 System and method for alleviating sleep apnea 0 2010
9,119,931 Mask system 0 2014
 
ORIEL THERAPEUTICS, INC. (9)
6,889,690 Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages 57 2003
7,677,411 Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders 0 2003
7,118,010 Apparatus, systems and related methods for dispensing and /or evaluating dry powders 17 2003
6,985,798 Dry powder dose filling systems and related methods 12 2003
7,451,761 Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances 23 2004
7,377,277 Blister packages with frames and associated methods of fabricating dry powder drug containment systems 7 2004
* 2005/0103,337 Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances 4 2004
7,520,278 Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages 15 2005
7,428,446 Dry powder dose filling systems and related methods 2 2005
 
BOSTON MEDICAL TECHNOLOGIES, INC. (4)
* 6,106,481 Method and apparatus for enhancing patient compliance during inspiration measurements 36 1997
* 5,984,954 Methods and apparatus for R-wave detection 6 1997
* 6,161,037 Methods and apparatus for R-wave detection 12 1999
6,436,053 Method and apparatus for enhancing patient compliance during inspiration measurements 18 2000
 
CAREFUSION 205, INC. (1)
7,007,696 Mask cushion and method of using same 57 2002
 
NOVARTIS PHARMA AG (4)
6,655,379 Aerosolized active agent delivery 46 1999
6,606,992 Systems and methods for aerosolizing pharmaceutical formulations 41 2000
7,185,651 Flow regulator for aerosol drug delivery and methods 5 2003
* 2005/0016,533 Systems and methods for aerosolizing pharmaceutical formulations 8 2003
 
RESMED LIMITED (117)
6,123,071 Facial masks for assisted respiration or CPAP 130 1996
6,112,746 Nasal mask and mask cushion therefor 284 1997
6,240,921 Automated stop/start control in the administration of CPAP treatment 27 1997
6,253,764 Control of delivery pressure in CPAP treatment or assisted respiration 27 1997
6,152,129 Determination of leak and respiratory airflow 86 1997
D428987 Nasal mask shell 60 1997
D423096 Nasal mask cushion 69 1997
6,138,675 Determination of the occurrence of an apnea 77 1997
6,532,957 Assisted ventilation to match patient respiratory need 66 1997
6,123,082 Device for preventing or reducing the passage of air through the mouth 60 1997
6,029,665 Determination of patency of airway 69 1997
6,332,463 Flow estimation and compensation of flow-induced pressure swings in CPAP treatment and assisted respiration 49 1997
6,494,207 Harness assembly for a nasal mask 80 1997
6,044,844 Mask and harness assembly 170 1997
6,213,119 Inspiratory duration in CPAP or assisted respiration treatment 80 1997
6,029,660 Substance delivery apparatus 80 1997
6,091,973 Monitoring the occurrence of apneic and hypopneic arousals 135 1997
6,119,693 Forehead support for facial mask 267 1998
6,367,474 Administration of CPAP treatment pressure in presence of APNEA 77 1998
6,237,592 Auto-calibration of pressure transducer offset 26 1998
6,561,190 Mask and a vent assembly therefor 113 1998
6,119,723 Apparatus for varying the flow area of a conduit 10 1998
6,237,593 Estimation of flow and detection of breathing CPAP treatment 15 1998
6,182,657 Pressure control in CPAP treatment or assisted respiration 15 1998
D421298 Flow generator 80 1998
6,336,454 Nasal ventilation as a treatment for stroke 13 1998
6,397,841 Apparatus for supplying breathable gas 50 1998
6,216,691 Mounting body 23 1998
6,513,526 Full-face mask and mask cushion therefor 147 1999
6,357,441 Nasal mask and mask cushion therefor 177 1999
6,561,191 Mask and a vent assembly therefor 57 1999
6,363,270 Monitoring the occurrence of apneic and hypopneic arousals 98 1999
6,279,569 Determination of leak and respiratory airflow 40 2000
6,634,358 Nasal mask cushion assembly 67 2000
6,463,931 Forehead support for facial mask 87 2000
6,526,974 Pressure control in CPAP treatment or assisted respiration 12 2000
6,776,155 Nasal ventilation as a treatment for stroke 5 2001
6,871,649 Nasal mask cushion assembly 35 2001
6,581,602 Nasal mask and mask cushion therefor 104 2002
7,178,527 Nasal mask and mask cushion therefor 14 2002
6,688,307 Methods and apparatus for determining instantaneous elastic recoil and assistance pressure during ventilatory support 40 2002
7,036,508 Harness assembly for a nasal mask 28 2002
6,557,556 Forehead support for facial mask 45 2002
6,701,927 Full-face mask and mask cushion therefor 93 2002
6,810,876 Assisted ventilation to match patient respiratory need 72 2002
6,691,708 Forehead support for facial mask 72 2002
6,860,269 Forehead support for facial mask 73 2002
7,845,354 Mask and vent assembly therefor 6 2002
6,973,929 Forehead support for a facial mask 17 2002
D498529 Portion of a cushion for use with a mask assembly in the application of continuous positive airway pressure (CPAP) 6 2003
7,207,335 Mask and vent assembly therefor 32 2003
7,302,950 Patient interface for respiratory apparatus 46 2003
8,522,785 Inextensible headgear and CPAP or ventilator mask assembly with the same 0 2003
6,997,188 Forehead support for facial mask 10 2003
7,234,466 Forehead support for facial mask 19 2003
7,069,933 Breathing mask and mask cushion therefor 11 2003
7,320,320 Determination of patency of the airway 4 2003
D550351 Elastic gas washout vent for a respiratory mask 2 2004
7,137,389 Method and apparatus for determining instantaneous inspired volume of a subject during ventilatory assistance 36 2004
7,503,327 Mask with integral cushion and forehead piece 29 2004
* 2005/0005,940 Mask with integral cushion and forehead piece 21 2004
7,406,965 Forehead support for facial mask 9 2004
7,243,651 Cushion and mask therefor 7 2004
* 2005/0139,219 Forehead support for facial mask 1 2005
7,942,150 Nasal assembly 23 2005
7,882,837 Forehead support for facial mask 7 2005
7,644,713 Method and apparatus for determining instantaneous leak during ventilatory assistance 26 2006
7,926,487 Respiratory mask having gas washout vent and gas washout vent assembly for a respiratory mask 13 2006
8,056,561 Full-face mask and mask cushion therefor 1 2006
7,610,916 Forehead support for facial mask 14 2006
8,122,886 Respiratory mask assembly with vent 0 2006
8,636,006 Mask 0 2007
7,931,023 Patient interface assembly for CPAP respiratory apparatus 16 2007
7,950,392 Cushion and mask therefor 1 2007
7,730,886 Determination of patency of the airway 0 2007
7,762,259 Mask with integral cushion and forehead piece 21 2007
8,517,023 Mask system with interchangeable headgear connectors 1 2008
8,869,797 Cushion and cushion to frame assembly mechanism for patient interface 0 2008
7,942,149 Forehead support for a facial mask 8 2009
8,550,084 Mask system 4 2009
8,186,348 Forehead support for facial mask 9 2009
8,051,853 Method and apparatus for providing ventilatory assistance 10 2009
8,505,535 Mask system 3 2009
8,360,060 Distinguishing between closed and open airway apneas and treating patients accordingly 0 2010
8,210,180 Mask with integral cushion and forehead piece 36 2010
8,381,722 Distinguishing between closed and open airway apneas and treating patients accordingly 1 2010
8,757,162 Nasal assembly 3 2010
8,833,371 Mask and vent assembly therefor 0 2010
8,528,558 Respiratory mask having washout vent and gas washout vent assembly for a respiratory mask 0 2011
8,353,294 Respiratory mask assembly 6 2011
8,646,450 Forehead support for a facial mask 0 2011
8,522,783 Cushion and mask therefor 1 2011
8,733,351 Method and apparatus for providing ventilatory assistance 0 2011
8,813,748 Full-face mask and mask cushion therefor 0 2011
8,684,000 Administration of CPAP treatment pressure in presence of apnea 0 2012
8,794,239 Mask with integral cushion and forehead piece 0 2012
8,485,192 Cushion for patient interface 1 2012
8,613,280 Cushion for patient interface 0 2012
8,573,213 Cushion for patient interface 0 2012
8,567,404 Cushion for patient interface 0 2012
8,573,214 Cushion for patient interface 1 2012
8,616,211 Cushion for patient interface 0 2012
8,613,281 Cushion for patient interface 0 2012
8,578,935 Cushion for patient interface 0 2012
8,573,215 Cushion for patient interface 0 2012
8,555,885 Cushion for patient interface 0 2012
8,550,081 Cushion for patient interface 0 2012
8,550,082 Cushion for patient interface 0 2012
8,550,083 Cushion for patient interface 0 2012
8,752,547 Distinguishing between closed and open airway apneas and treating patients accordingly 0 2012
8,528,561 Mask system 4 2013
9,027,556 Mask system 0 2013
8,991,395 Mask system 0 2013
8,522,784 Mask system 12 2013
8,826,910 Mask and vent assembly therefor 0 2013
8,944,061 Cushion to frame assembly mechanism 0 2013
8,960,196 Mask system with interchangeable headgear connectors 0 2013
 
MEDTRONIC, INC. (1)
* 6,928,338 Decision information system for drug delivery devices 38 2002
 
INVACARE CORPORATION (5)
7,290,546 Nasal mask 20 2003
7,621,274 Nasal mask 40 2003
D507831 Nasal mask 7 2004
D583931 Nasal mask 0 2004
8,028,698 Breathing mask 0 2007
 
PROFILE RESPIRATORY SYSTEMS LIMITED (2)
8,967,140 Controlling drug delivery apparatus 0 2001
* 2001/0022,279 Controlling drug delivery apparatus 13 2001
 
Vermeer Manufacturing Company (1)
6,740,046 Method and apparatus for enhancing patient compliance during inspiration measurements 18 2002
 
CLAVIUS DEVICES INC., A CORPORATION ORGANIZED UNDER THE LAWS OF THE STATE OF NEW YORK (4)
6,260,549 Breath-activated metered-dose inhaler 60 1998
6,425,392 Breath-activated metered-dose inhaler 63 1999
6,325,062 Breath-activated metered-dose inhaler 16 1999
6,318,361 Breath-activated metered-dose inhaler 50 1999
 
BATTELLE MEMORIAL INSTITUTE (1)
7,607,435 Gas or liquid flow sensor 9 2004
 
RESPIRONICS (UK) LTD. (1)
* 7,451,760 Controlling drug delivery apparatus 2 2001
 
CANON KABUSHIKI KAISHA (1)
8,333,188 Medicine ejection apparatus and control method thereof 0 2009
 
ASTRAZENECA AB (1)
6,986,904 Formulation 8 2003
 
MAP-MEDIZINTECHNOLOGIE GMBH (2)
7,775,209 Breathing mask for feeding a breathing gas to a mask user and discharge device for discharging breathing gas 32 2006
8,746,250 Breathing mask for feeding a breathing gas to a mask user and discharge device for discharging breathing gas 1 2013
 
ASTRA AKTIEBOLAG (2)
* 6,291,445 Low dose budesonide formulations and uses thereof 13 1997
6,686,346 Formulation 22 2001
 
BOEHRINGER INGELHEIM INTERNATIONAL GMBH (1)
* 2011/0277,753 DISPENSING DEVICE, STORAGE DEVICE AND METHOD FOR DISPENSING A FORMULATION 0 2008
 
Philip Morris USA Inc. (1)
* 7,128,067 Method and apparatus for generating an aerosol 15 2003
 
SYDNEY SOUTH WEST AREA HEALTH SERVICE (1)
* 5,817,028 Method and device for the provocation of air passage narrowing and/or the induction of sputum 54 1996
 
HILL-ROM SERVICES PTE. LTD (1)
8,251,876 Breathing exercise apparatus 0 2008
 
GLAXO GROUP LIMITED (1)
* 5,795,594 Salmeterol xinafoate with controlled particle size 50 1996
 
RESMED R&D GERMANY GMBH (11)
7,100,610 Breathing mask for feeding a breathing gas to a mask user and discharge device for discharging breathing gas 36 2001
7,000,614 Breathing mask arrangement and a forehead support device for same 55 2002
7,320,323 Breathing mask device and application device and frontal support device thereof 27 2002
7,654,263 Breathing mask arrangement and a forehead support device for same 22 2005
7,967,014 Application device for breathing mask arrangement 16 2006
7,992,559 Breathing mask arrangement as well as an application device and a forehead support device for same 20 2007
8,402,972 Breathing mask arrangement and a forehead support device for same 3 2009
8,371,301 Breathing mask for feeding a breathing gas to a mask user and discharge device for discharging breathing gas 3 2010
9,072,853 Forehead pad for respiratory mask 0 2010
8,875,710 Application device for a breathing mask arrangement 0 2011
8,479,738 Breathing mask arrangement as well as an application device and a forehead support device for same 2 2011
 
ARADIGM CORPORATION (21)
* 5,915,378 Creating an aerosolized formulation of insulin 139 1995
* 5,888,477 Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin 43 1997
* 5,855,564 Aerosol extrusion mechanism 37 1997
* 6,131,567 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 46 1998
* 6,085,753 Insulin delivery enhanced by coached breathing 37 1998
* 6,098,615 Method of reproducibly effecting a patient's glucose level 37 1998
* 5,970,973 Method of delivering insulin lispro 54 1998
* 5,873,358 Method of maintaining a diabetic patient's blood glucose level in a desired range 17 1998
* 6,024,090 Method of treating a diabetic patient by aerosolized administration of insulin lispro 16 1998
* 5,971,951 Aerosol extrusion mechanism 45 1998
6,408,854 Insulin delivery enhanced by coached breathing 28 2000
6,250,298 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 38 2000
6,431,166 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 22 2001
6,427,681 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 5 2001
6,431,167 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 9 2001
6,830,744 Compositions methods and systems for pulmonary delivery of recombinant human interferon alpha-2b 0 2002
6,647,987 Insulin delivery enhanced by coached breathing 3 2002
7,021,309 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 3 2003
7,278,419 Method for treating diabetes mellitus in a patient 6 2004
7,448,375 Method of treating diabetes mellitus in a patient 5 2005
7,490,603 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 1 2005
* Cited By Examiner