Method of treating retained pulmonary secretions
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United States of America Patent
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Apr 30, 1996
Grant Date -
N/A
app pub date -
Jun 9, 1993
filing date -
Jun 9, 1993
priority date (Note) -
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status (Latency Note)
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Abstract
A method of facilitating the clearance of retained pulmonary secretions in a subject using lantibiotics is disclosed. The method comprises administering to the lungs of the subject an effective amount of a lantibiotic. The lantibiotic is preferably administered by topically applying it to the respiratory epithelia, such as by generating an aerosol thereof which is then inhaled by the subject. A preferred lantibiotic for carrying out the present invention is duramycin. The method may be used in treating disorders such as cystic fibrosis, chronic bronchitis, and asthma. Also disclosed is a method of combatting tuberculosis comprising administering a lantibiotic to a subject in need of such treatment.
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