Oligonucleotide-linked magnetic particles and uses thereof
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United States of America Patent
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Apr 30, 1996
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N/A
app pub date -
Jul 6, 1994
filing date -
Nov 21, 1988
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Abstract
Monodisperse, superparamagnetic particles carrying a plurality of molecules of an oligonucleotide are disclosed and may be used inter alia for sequencing single-stranded nucleic acids. The oligonucleotide may be covalently attached or affinity bonded to the particles either by their 3' or 5' termini. The particles have a specific gravity in the range 1.1-1.8 and are 1-10 microns in diameter. A kit for the isolation or processing of target nucleic acid is also disclosed.
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