Waveguide immunosensor with coating chemistry providing enhanced sensitivity
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United States of America Patent
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Apr 30, 1996
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N/A
app pub date -
May 18, 1993
filing date -
May 18, 1993
priority date (Note) -
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Abstract
Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide and optionally has multi-well features and improved evanescent field intensity. The preferred biosensor and assay method have the capture molecules immobilized to the waveguide surface by site-specific coupling chemistry. Additionally, the coatings used to immobilize the capture molecules provide reduced non-specific protein adsorption.
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