US Patent No: 5,516,637

Number of patents in Portfolio can not be more than 2000

Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage

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Abstract

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The present invention relates to a fusion protein, comprising a pilin protein or a portion thereof and a heterologous polypeptide (target protein). In a preferred embodiment it relates to a method for displaying the target protein on the outer surface of a bacterial host cell capable of forming pilus. In certain embodiments, it is desirable that the pilus is a receptor for bacteriophage attachment and infection. The F pilus is preferred.

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First Claim

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Patent Owner(s)

  • DADE BEHRING INC.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Huang, Grace P Miami, FL 1 169
Rhode, Peter R Miami, FL 10 269
Stinson, Jeffrey R Davie, FL 24 360
Wong, Hing C Ft. Lauderdale, FL 68 546

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (2)
* 5,223,409 Directed evolution of novel binding proteins 1316 1991
* 5,348,867 Expression of proteins on bacterial surface 66 1991
* Cited By Examiner

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (267)
* 5,922,537 Nanoparticles biosensor 186 1996
7,041,441 Phage display of intact domains at high copy number 3 1997
* 6,040,136 Enrichment method for variant proteins with altered binding properties 40 1997
* 5,981,249 Single-chain polypeptides comprising creatine kinase M and creatine kinase B 0 1998
* 6,165,722 Representations of bimolecular interactions 5 1999
6,475,785 Single-chain polypeptides comprising troponin I N-terminal fragments and troponin C 2 1999
* 6,479,280 Recombinant phages capable of entering host cells via specific interaction with an artificial receptor 3 1999
* 7,355,015 Matriptase, a serine protease and its applications 2 2000
7,429,646 Antibodies to human tumor necrosis factor receptor-like 2 2 2000
6,994,982 Isolating biological modulators from biodiverse gene fragment libraries 2 2000
* 2004/0001,826 Glycoprotein VI and uses thereof 8 2001
7,297,762 Modified avian pancreatic polypeptide miniature binding proteins 0 2001
7,597,886 Tumor necrosis factor-gamma 5 2001
* 2002/0150,534 Tumor necrosis factor-gamma 11 2001
7,060,462 AopB gene, protein,homologs, fragments and variants thereof, and their use for cell surface display 1 2001
* 2003/0068,320 Methods of administering/dosing CD2 antagonists for the prevention and treatment of autoimmune disorders or inflammatory disorders 35 2002
7,125,679 Methods to screen peptide libraries using minicell display 18 2002
* 2003/0039,958 Direct screening method 6 2002
* 2006/0239,533 Method for detecting infectious agents using computer controlled automated image analysis 11 2002
* 2003/0044,863 Invasion complex and methods of targeting 3 2002
6,867,189 Use of adipsin/complement factor D in the treatment of metabolic related disorders 5 2002
* 2003/0091,593 In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles 19 2002
* 2003/0148,508 Recombinant phages capable of entering host cells via specific interaction with an artificial receptor 1 2002
* 2007/0166,704 Identification of polynucleotides and polypeptide for predicting activity of compounds that interact with protein tyrosine kinases and/or protein tyrosine kinase pathways 12 2003
* 2006/0046,249 Identification of polynucleotides and polypetide for predicting activity of compounds that interact with protein tyrosine kinase and or protein tyrosine kinase pathways 28 2003
7,270,969 Methods of constructing and screening diverse expression libraries 6 2003
* 2003/0215,846 Methods of constructing and screening diverse expression libraries 2 2003
* 2003/0219,842 Assays for cancer patient monitoring based on levels of epidermal growth factor receptor (EGFR) extracellular domain (ECD) analyte, alone or in combination with other analytes, in body fluid samples 2 2003
7,294,701 Antibody fragment capable of modulating multidrug resistance and compositions and kits and methods using same 2 2003
* 2004/0197,334 Antibody fragment capable of modulating multidrug resistance and compositions and kits and methods using same 1 2003
* 2004/0010,116 Minicell display and products therefrom 1 2003
* 2003/0235,864 Method to screen ligands using eukaryotic cell display 4 2003
7,563,882 Polynucleotides encoding antibodies that bind to the C35 polypeptide 21 2003
* 2004/0063,907 Gene differentially expressed in breast and bladder cancer and encoded polypeptides 4 2003
* 2004/0076,976 Aopb gene, protein,homologs, fragments and variants thereof, and their use for cell surface display 0 2003
* 2004/0265,315 Methods of preventing or treating T cell malignancies by administering CD2 antagonists 2 2003
7,427,469 Method of treating cytomegalovirus with DC-SIGN blockers 2 2003
7,419,789 Method of inhibiting binding of Dengue virus to a human cell with DC-SIGN blockers 0 2003
* 2006/0134,100 Dc-sign blockers and their use for preventing or treating viral infections 3 2003
* 2004/0197,330 Compositions comprising DC-SIGN blockers and methods of using DC-SIGN blockers for preventing or treating diseases of a mammal, including viral infections 0 2003
7,259,002 Polynucleotide encoding a novel acyl coenzyme A, monoacylglycerol acyltransferase-3 (MGAT3), and uses thereof 0 2004
7,803,765 Methods of constructing biodiverse gene fragment libraries and biological modulators isolated therefrom 2 2004
* 2007/0031,832 Methods of constructing biodiverse gene fragment libraries and biological modulators isolated therefrom 18 2004
7,785,829 Nogo receptor binding protein 9 2004
* 2007/0059,793 Nogo receptor binding protein 8 2004
7,101,549 Glycoprotein VI and uses thereof 4 2004
* 2004/0253,236 Glycoprotein VI and uses thereof 0 2004
7,393,534 Compositions and methods for immunotherapy of cancer and infectious diseases 0 2004
* 2005/0169,935 Compositions and methods for immunotherapy of cancer and infectious diseases 3 2004
* 2005/0058,658 Compositions and methods for immunotherapy of human immunodeficiency virus (HIV) 2 2004
7,582,461 Kinase and phosphatase assays 4 2004
* 2005/0054,573 Kinase and phosphatase assays 19 2004
7,619,059 Bimolecular optical probes 1 2004
* 2005/0170,442 Bimolecular optical probes 22 2004
* 2007/0274,988 Kiaa0779, Splice Variants Thereof, and Methods of Their Use 0 2004
* 2007/0148,172 Method for the treatment of inflammatory bowel disease 5 2004
7,495,070 Protein binding miniature proteins 0 2004
* 2007/0269,428 Method for the Treatment of Multiple Sclerosis by Inhibiting Il-17 Activity 8 2004
* 2005/0158,323 Methods of killing tumor cells by targeting internal antigens exposed on apoptotic tumor cells 8 2004
7,736,635 Branched molecular scaffolds for linking polymer residues to biologically active moieties 0 2004
* 2007/0128,150 Branched molecular scaffolds for linking polymer residues to biologically active moieties 0 2004
* 2005/0266,425 Methods for producing and identifying multispecific antibodies 5 2004
8,318,905 Antibodies for depletion of ICOS-positive cells in vivo 0 2005
* 2006/0292,554 Major coat protein variants for C-terminal and bi-terminal display 1 2005
* 2011/0218,118 PEPTIDE MODULATORS OF CELLULAR PHENOTYPE AND BI-NUCLEIC ACID FRAGMENT LIBRARY 1 2005
8,486,893 Treatment of conditions involving demyelination 3 2005
* 2006/0068,379 Phage display of intact domains at high copy number 0 2005
* 2006/0009,388 Treatment of conditions involving demyelination 13 2005
* 2005/0287,580 Isolating biological modulators from biodiverse gene fragment libraries 4 2005
8,211,430 Methods and pharmaceutical compositions for treating type 1 diabetes mellitus and other conditions 2 2006
* 2006/0269,556 Mast cell activation using siglec 6 antibodies 0 2006
7,393,919 Peptides, derivatives and analogs thereof, and methods of using same 12 2006
* 2007/0087,971 Peptides, derivatives and analogs thereof, and methods of using same 6 2006
* 2006/0216,291 Glycoprotein VI and uses thereof 4 2006
7,700,739 IL-12/p40 binding proteins 7 2006
7,597,888 Glycoprotein VI and uses thereof 4 2006
* 2008/0050,380 Glycoprotein VI and uses thereof 6 2006
7,482,124 Method of identifying a PPARgamma-agonist compound having a decreased likelihood of inducing dose-dependent peripheral edema 0 2006
* 2007/0009,945 Single nucleotide polymorphisms associated with dose-dependent edema and methods of use thereof 2 2006
* 2007/0048,793 Compositions and methods for biocatalytic engineering 0 2006
7,727,752 Kinase and phosphatase assays 4 2006
* 2007/0059,787 Kinase and phosphatase assays 2 2006
7,612,181 Dual variable domain immunoglobulin and uses thereof 78 2006
8,129,505 Comb polymers 0 2006
* 2008/0220,005 Comb Polymers 0 2006
* 2007/0072,221 Methods to screen peptide display libraries using minicell display 1 2006
8,906,864 Binding domains of proteins of the repulsive guidance molecule (RGM) protein family and functional fragments thereof, and their use 0 2006
* 2009/0297,527 Binding Domains of Proteins of the Repulsive Guidance Molecule (RGM) Protein Family and Functional Fragments Thereof, and Their Use 7 2006
* 2007/0025,990 Methods of administering/dosing CD2 antagonists for the prevention and treatment of autoimmune disorders or inflammatory disorders 17 2006
* 2007/0117,126 SHOTGUN SCANNING 6 2006
8,691,224 Anti-Aβ globulomer 5F7 antibodies 0 2006
8,497,072 Amyloid-beta globulomer antibodies 0 2006
8,075,889 Antibody molecules having specificity for human IL-6 0 2006
* 2007/0154,481 Antibody Molecules Having Specificity For Human IL-6 13 2006
8,946,381 Compositions and uses thereof for the treatment of wounds 0 2007
* 2010/0166,835 Compositions and uses thereof for the treatment of wounds 0 2007
8,575,070 Methods of constructing and screening libraries of peptide structures 0 2007
7,611,858 Detection of cannabinoid receptor biomarkers and uses thereof 0 2007
* 2009/0170,722 Methods of constructing and screening diverse expression libraries 3 2007
8,460,667 EPHA2 receptor antagonist antibodies 1 2007
* 2010/0047,257 ANTAGONIST ANTIBODY FOR THE TREATMENT OF CANCER 9 2007
7,820,798 Tumor necrosis factor-gamma 1 2007
* 2007/0297,977 Tumor Necrosis Factor-Gamma 3 2007
8,551,476 SP35 antibodies and uses thereof 3 2007
7,750,125 Antibodies that bind to the C35 polypeptide 16 2007
* 2008/0089,886 Gene differentially expressed in breast and bladder cancer and encoded polypeptides 5 2007
7,915,388 Interleukin-13 binding proteins 15 2007
* 2009/0142,338 Methods and Compositions for Treating Type 1 and Type 2 Diabetes Mellitus and Related Conditions 10 2007
8,153,765 Anti-CD38 antibodies for the treatment of cancer 1 2007
* 2009/0304,710 NOVEL ANTI-CD38 ANTIBODIES FOR THE TREATMENT OF CANCER 8 2007
8,785,400 Methods and compositions relating to islet cell neogenesis 0 2007
* 2009/0068,145 Methods and Compositions Relating to Islet Cell Neogenesis 5 2007
8,455,626 Aβ conformer selective anti-aβ globulomer monoclonal antibodies 0 2007
7,732,159 Assays for cancer patient monitoring based on levels of analyte components of the plasminogen activator system in body fluid samples 0 2007
8,114,606 ARL-1 specific antibodies 0 2008
8,895,004 Method for the treatment of amyloidoses 0 2008
7,885,449 System for detecting infectious agents using computer-controlled automated image analysis 0 2008
7,807,168 Selection of human TNFα specific antibodies 0 2008
8,257,714 Compositions and methods for immunotherapy of cancer and infectious diseases 0 2008
* 2009/0136,999 COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY OF CANCER AND INFECTIOUS DISEASES 0 2008
* 2008/0268,456 METHOD FOR DETECTING AND QUANTITATING MULTIPLE-SUBCELLULAR COMPONENTS 0 2008
* 2009/0081,199 Novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof 2 2008
7,714,103 Peptides, derivatives and analogs thereof, and methods of using same 5 2008
* 2008/0300,190 PEPTIDES, DERIVATIVES AND ANALOGS THEREOF, AND METHODS OF USING SAME 7 2008
* 2009/0081,210 Methods of Killing Tumor Cells by Targeting Internal Antigens Exposed on Apoptotic Tumor Cells 4 2008
* 2009/0232,801 Humanized Antibodies Which Bind To AB (1-42) Globulomer And Uses Thereof 23 2008
8,822,409 Compositions and uses thereof for the treatment of acute respiratory distress syndrome (ARDS) and clinical disorders associated with therewith 0 2008
8,685,893 Phage display 0 2008
* 2009/0048,209 COMPOSITIONS COMPRISING DC-SIGN BLOCKERS AND METHODS OF USING DC-SIGN BLOCKERS FOR PREVENTING OR TREATING DISEASES OF A MAMMAL, INCLUDING VIRAL INFECTIONS 0 2008
8,816,047 Compositions and methods of using proislet peptides and analogs thereof 0 2008
* 2011/0171,178 COMPOSITIONS AND METHODS OF USING PROISLET PEPTIDES AND ANALOGS THEREOF 3 2008
* 2010/0322,948 Bone morphogenetic protein (BMP)-binding domains of proteins of the repulsive guidance molecule (RGM) protein family and functional fragments thereof, and use of same 6 2008
7,824,675 Use of an antibody that binds human tumor necrosis factor receptor-like 2 1 2008
* 2010/0297,121 Methods for Treating Pressure Induced Optic Neuropathy, Preventing Neuronal Degeneration and Promoting Neuronal Cell Survival Via Administration of LINGO-1 Antagonists and TrkB Agonists 20 2008
* 2011/0123,553 Use of LINGO-4 Antagonists in the Treatment of Conditions Involving Demyelination 7 2008
7,931,900 Method for the treatment of multiple sclerosis by inhibiting IL-17 activity 2 2008
9,308,257 Protein formulation 0 2008
* 2010/0303,827 Protein Formulation 4 2008
8,637,026 Anti-C35 antibody combination therapies and methods 0 2008
7,968,688 Antibodies that bind to the C35 polypeptide 0 2009
7,879,990 Polynucleotides encoding antibodies that bind to the C35 polypeptide 0 2009
8,962,803 Antibodies against the RGM A protein and uses thereof 0 2009
* 2010/0028,340 ANTIBODIES AGAINST THE RGM A PROTEIN AND USES THEREOF 18 2009
8,128,926 Sp35 antibodies and uses thereof 10 2009
* 2009/0269,786 RHO1-Gamma Amino Butyric Acid C Receptor-Specific Antibodies 0 2009
9,029,508 Dual variable domain immunoglobulins and uses thereof 0 2009
8,323,651 Antibodies to receptor of advanced glycation end products (RAGE) and uses thereof 3 2009
* 2010/0028,359 ANTIBODIES TO RECEPTOR OF ADVANCED GLYCATION END PRODUCTS (RAGE) AND USES THEREOF 5 2009
9,109,026 Dual variable domain immunoglobulins and uses thereof 0 2009
9,035,027 Dual variable domain immunoglobulins and uses thereof 1 2009
* 2009/0311,253 Dual Variable Domain Immunoglobulins and Uses Thereof 33 2009
* 2009/0304,693 Dual Variable Domain Immunoglobulins and Uses Thereof 32 2009
8,231,878 Receptor trem (triggering receptor expressed on myeloid cells) and uses thereof 0 2009
* 2010/0310,560 Novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof 3 2009
8,258,268 Dual variable domain immunoglobulin and uses thereof 31 2009
* 2010/0047,239 Dual variable domain immunoglobulin and uses thereof 39 2009
8,822,645 Prostaglandin E2 dual variable domain immunoglobulins and uses thereof 9 2009
* 2010/0074,900 PROSTAGLANDIN E2 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF 19 2009
8,058,406 Composition comprising antibodies to LINGO or fragments thereof 9 2009
* 2010/0015,131 Composition Comprising Antibodies to LINGO or Fragments Thereof 7 2009
* 2010/0167,320 Compositions and Methods for Detecting and Quantifying Toxic Substances in Disease States 4 2009
* 2010/0233,079 Dual Variable Domain Immunoglobulins and Uses Thereof 17 2009
7,989,415 Peptides, derivatives and analogs thereof, and methods of using same 4 2009
8,852,608 Antibodies against and methods for producing vaccines for respiratory syncytial virus 0 2009
8,137,923 Glycoprotein VI and uses thereof 1 2010
* 2010/0261,200 Glycoprotein VI and Uses Thereof 0 2010
* 2010/0310,591 Ii-KEY HYBRID PEPTIDES THAT MODULATE THE IMMUNE RESPONSE TO INFLUENZA 0 2010
8,383,778 IL-1 binding proteins 1 2010
* 2010/0221,179 IL-1 Binding Proteins 8 2010
* 2010/0216,975 Framework-Shuffling Of Antibodies 1 2010
8,614,295 Antibody molecules having specificity for human OX40 0 2010
* 2010/0254,978 ANTIBODY MOLECULES HAVING SPECIFICITY FOR HUMAN OX40 3 2010
8,835,610 IL-17 binding proteins 6 2010
* 2010/0266,531 IL-17 BINDING PROTEINS 18 2010
8,691,233 Antibody molecules having binding specificity for human IL-13 0 2010
* 2010/0260,773 ANTIBODY MOLECULES HAVING BINDING SPECIFICITY FOR HUMAN IL-13 0 2010
8,067,536 Kinase and phosphatase assays 2 2010
8,629,257 IL-12/p40 binding proteins 0 2010
* 2011/0044,980 Dual Variable Domain Immunoglobulins and Uses Thereof 16 2010
8,568,719 Antibodies against human respiratory syncytial virus (RSV) and methods of use 1 2010
* 2011/0076,268 Antibodies against human respiratory syncytial virus (RSV) and methods of use 1 2010
8,623,358 Therapeutic DLL4 binding proteins 3 2010
8,586,714 Dual variable domain immunoglobulins and uses thereof 12 2010
* 2011/0091,372 Dual Variable Domain Immunoglobulins and Uses Thereof 13 2010
8,093,363 Tumor necrosis factor-gamma 0 2010
8,668,910 Antibodies that specifically bind to the EphA2 receptor 0 2010
8,716,450 Dual variable domain immunoglobulins and uses thereof 13 2010
9,067,995 Method to generate antibodies to ion channels 0 2010
8,926,977 Antibodies to the E1 extracellular loop of ion channels 0 2010
8,734,798 Function modifying NAv 1.7 antibodies 0 2010
* 2011/0135,662 FUNCTION MODIFYING NAv 1.7 ANTIBODIES 5 2010
8,722,855 Dual variable domain immunoglobulins and uses thereof 10 2010
8,420,083 Antibodies to receptor for advanced glycation end products (RAGE) and uses thereof 0 2010
* 2011/0212,094 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF 16 2010
9,175,075 Methods of treating retinal nerve fiber layer degeneration with monoclonal antibodies against a retinal guidance molecule (RGM) protein 0 2010
* 2011/0135,664 MONOCLONAL ANTIBODIES AGAINST THE RGM A PROTEIN FOR USE IN THE TREATMENT OF RETINAL NERVE FIBER LAYER DEGENERATION 6 2010
8,937,169 Human G-protein chemokine receptor HSATU68 0 2011
8,685,666 ARL-1 specific antibodies and uses thereof 0 2011
* 2011/0195,411 ARL-1 SPECIFIC ANTIBODIES AND USES THEREOF 1 2011
9,115,195 Therapeutic DLL4 binding proteins 0 2011
8,604,177 Interleukin-13 binding proteins 0 2011
* 2011/0165,066 INTERLEUKIN-13 BINDING PROTEINS 0 2011
9,045,529 Disulfide stabilized antibodies and fragments thereof 0 2011
8,987,419 Amyloid-beta binding proteins 0 2011
9,011,852 Anti-C5a antibodies 3 2011
8,877,190 Aβ conformer selective anti-Aβ globulomer monoclonal antibodies 0 2011
8,841,417 IL-1 binding proteins 0 2011
* 2011/0229,909 RHO1-Gamma Amino Butyric Acid C Receptor-Specific Antibodies 0 2011
8,383,578 Peptides, derivatives and analogs thereof, and methods of using same 1 2011
9,139,642 Anti-human respiratory syncytial virus (RSV) antibodies and methods of use 0 2011
9,273,111 Therapeutic TREM-1 peptides 0 2011
9,127,057 Anti-IL-23 heterodimer specific antibodies 0 2011
9,176,150 Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof 0 2011
8,735,546 Dual variable domain immunoglobulins and uses thereof 10 2011
9,062,101 Amyloid-beta binding proteins 0 2011
9,046,513 Dual variable domain immunoglobulins and uses thereof 0 2011
8,425,910 Composition comprising antibodies to LINGO or fragments thereof 3 2011
8,486,662 DNA encoding antibody molecules having specificity for human IL-6 2 2011
8,580,265 Antibody molecules which bind IL-17A and IL-17F 1 2012
8,609,407 Sp35 antibodies and uses thereof 3 2012
8,765,662 NOGO receptor binding protein 3 2012
9,181,553 Method of treatment of breast cancers over-expressing the SHP2 signature genes 0 2012
9,244,074 Biomarker of asbestos exposure and mesothelioma 0 2012
8,680,239 Use of RGM and its modulators 0 2012
9,234,037 Method to generate antibodies to ion channels 0 2012
8,916,155 Method for the treatment of T cell mediated conditions by depletion of ICOS-positive cells in vivo 0 2012
9,220,774 Methods of treating cancer by administering anti-GPR49 antibodies 0 2012
9,221,906 Methods of inhibiting solid tumor growth by administering GPR49 antibodies 0 2012
9,221,907 Anti-GPR49 monoclonal antibodies 0 2012
9,394,363 Antibodies to receptor of advanced glycation end products (RAGE) and uses thereof 0 2012
9,000,127 Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) 0 2012
8,981,061 Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof 0 2012
9,120,870 Dual specific binding proteins directed against IL-13 and IL-17 0 2012
8,829,158 Peptides, derivatives and analogs thereof, and methods of using same 0 2013
9,068,992 Screening methods for identifying Sp35 antagonists 0 2013
8,932,821 NOGO receptor binding protein 0 2013
9,066,984 Sp35 antibodies and uses thereof 0 2013
9,067,996 Antibodies to receptor for advanced glycation end products (RAGE) and uses thereof 0 2013
8,664,367 IL-I binding proteins 0 2013
9,359,430 Abeta conformer selective anti-Abeta globulomer monoclonal antibodies 0 2013
9,096,668 Methods for making antibody molecules having specificity for human IL-6 0 2013
8,779,101 IL-17 binding proteins 1 2013
9,365,638 Antibodies against human respiratory syncytial virus (RSV) and methods of use 0 2013
9,102,722 Composition and method for the diagnosis and treatment of diseases associated with neurite degeneration 0 2013
9,365,641 Compositions and methods for targeting stromal cells for the treatment of cancer 0 2013
9,273,142 Glycan-interacting compounds 0 2013
9,163,093 Anti-DLL4/VEGF dual variable domain immunoglobulin and uses thereof 0 2013
9,034,600 DNA encoding antibody molecules which bind IL-17A and IL-17F 0 2013
9,132,190 Therapeutic DLL4 binding proteins 0 2013
9,303,085 IL-1 binding proteins 0 2013
9,371,374 HCV core lipid binding domain monoclonal antibodies 0 2013
9,259,467 Mammalian receptors as targets for antibody and active vaccination therapy against mold infections 0 2013
9,394,361 Isolated DNA sequences encoding, and methods for making, antibody molecules having binding specificity for human IL-13 0 2014
9,062,108 Dual specific binding proteins directed against IL-1 and/or IL-17 0 2014
8,986,954 1.7 antibodies 0 2014
9,045,551 Anti-DLL4/VEGF dual variable domain immunoglobulin and uses thereof 0 2014
8,987,418 Dual specific binding proteins directed against IL-1β and/or IL-17 1 2014
8,992,927 Targeting human NAV1.7 variants for treatment of pain 0 2014
8,986,694 Targeting human nav1.7 variants for treatment of pain 0 2014
9,394,360 Aβ conformer selective anti-Aβ globulomer monoclonal antibodies 0 2014
9,062,105 Precision Medicine by targeting VEGF-A variants for treatment of retinopathy 0 2014
9,045,545 Precision medicine by targeting PD-L1 variants for treatment of cancer 0 2014
9,067,998 Targeting PD-1 variants for treatment of cancer 0 2014
9,365,643 Antibodies that bind to repulsive guidance molecule A (RGMA) 0 2014
9,221,901 Methods of treating complement-associated disorders with anti-C5a antibodies 1 2015
9,309,310 Nucleic acids encoding anti-C5a antibodies 1 2015
9,371,378 Anti-C5a antibodies 0 2016
* Cited By Examiner