Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage

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United States of America Patent

PATENT NO 5516637
SERIAL NO

08258026

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Abstract

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The present invention relates to a fusion protein, comprising a pilin protein or a portion thereof and a heterologous polypeptide (target protein). In a preferred embodiment it relates to a method for displaying the target protein on the outer surface of a bacterial host cell capable of forming pilus. In certain embodiments, it is desirable that the pilus is a receptor for bacteriophage attachment and infection. The F pilus is preferred.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
DADE BEHRING INC.DEERFIELD, IL1

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Huang, Grace P Miami, FL 1 231
Rhode, Peter R Miami, FL 10 364
Stinson, Jeffrey R Davie, FL 24 486
Wong, Hing C Ft. Lauderdale, FL 75 745

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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DYAX CORP. (1)
* 5223409 Directed evolution of novel binding proteins 1537 1991
* Cited By Examiner

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* 2009/0136,999 COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY OF CANCER AND INFECTIOUS DISEASES 0 2008
 
NATIONAL UNIVERSITY OF SINGAPORE (2)
7060462 AopB gene, protein,homologs, fragments and variants thereof, and their use for cell surface display 1 2001
* 2004/0076,976 Aopb gene, protein,homologs, fragments and variants thereof, and their use for cell surface display 0 2003
 
BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY (3)
8114606 ARL-1 specific antibodies 0 2008
8685666 ARL-1 specific antibodies and uses thereof 0 2011
* 2011/0195,411 ARL-1 SPECIFIC ANTIBODIES AND USES THEREOF 2 2011
 
CRUCELL HOLLAND B.V. (5)
8568719 Antibodies against human respiratory syncytial virus (RSV) and methods of use 5 2010
* 2011/0076,268 Antibodies against human respiratory syncytial virus (RSV) and methods of use 5 2010
9139642 Anti-human respiratory syncytial virus (RSV) antibodies and methods of use 1 2011
9365638 Antibodies against human respiratory syncytial virus (RSV) and methods of use 0 2013
9403900 Anti-human respiratory syncytial virus (RSV) antibodies and methods of use 0 2014
 
SCHOLAR ROCK, INC. (3)
9758576 Compositions and methods for growth factor modulation 0 2015
9573995 Compositions and methods for growth factor modulation 0 2015
9399676 Compositions and methods for growth factor modulation 2 2015
 
BIOXELL S.P.A. (1)
* 2009/0081,199 Novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof 7 2008
 
LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER (1)
9259467 Mammalian receptors as targets for antibody and active vaccination therapy against mold infections 0 2013
* Cited By Examiner