US Patent No: 5,516,781

Number of patents in Portfolio can not be more than 2000

Method of treating restenosis with rapamycin

3 Status Updates

Stats

ATTORNEY / AGENT: (SPONSORED)
 

Importance

Loading Importance Indicators... loading....

Abstract

This invention provides a method of preventing or treating hyperproliferative vascular disease in a mammal by administering an antiproliferative effective amount of rapamycin alone or in combination with mycophenolic acid.

Loading the Abstract Image... loading....

First Claim

Related Publications

Loading Related Publications... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
WYETHMADISON, NJ2039

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gregory, Clare R Menlo Park, CA 3 348
Morris, Randall E Basel, CH 7 391

Cited Art

Patent Info (Count) # Cites Year
 
WYETH (5)
5,078,999 Method of treating systemic lupus erythematosus 116 1991
5,080,899 Method of treating pulmonary inflammation 119 1991
5,288,711 Method of treating hyperproliferative vascular disease 138 1992
5,256,790 27-hydroxyrapamycin and derivatives thereof 28 1993
5,252,579 Macrocyclic immunomodulators 75 1993
 
HITACHI, LTD. (1)
2005/0186,696 Gas flowmeter and manufacturing method thereof 2005
 
WYETH-AYERST CANADA INC. (1)
4,885,171 Use of rapamycin in treatment of certain tumors 156 1984
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (1)
5,100,899 Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof 158 1989

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
WYETH (30)
5,665,728 Method of treating hyperproliferative vascular disease 65 1995
5,780,462 Water soluble rapamycin esters 36 1996
5,955,457 Water soluble rapamycin esters 10 1998
5,922,730 Alkylated rapamycin derivatives 18 1998
6,015,809 Photocyclized rapamycin 33 1999
6,117,863 Photocyclized rapamycin 1 1999
8,029,561 Drug combination useful for prevention of restenosis 0 2000
6,776,796 Antiinflammatory drug and delivery device 89 2001
7,261,735 Local drug delivery devices and methods for maintaining the drug coatings thereon 45 2001
6,432,973 Water soluble rapamycin esters 23 2001
6,399,625 1-oxorapamycins 9 2001
6,440,991 Ethers of 7-desmethlrapamycin 16 2001
6,399,626 Hydroxyesters of 7-desmethylrapamycin 10 2001
8,303,609 Coated medical devices 0 2001
7,195,640 Coated medical devices for the treatment of vulnerable plaque 53 2002
6,617,333 Antineoplastic combinations comprising 22 2002
6,680,330 Rapamycin dialdehydes 20 2002
6,677,357 Rapamycin 29-enols 24 2002
7,108,701 Drug releasing anastomosis devices and methods for treating anastomotic sites 41 2002
6,670,355 Method of treating cardiovascular disease 15 2002
7,189,735 Use of CCI-779 as an antineoplastic agent 2 2003
7,056,550 Medical devices, drug coatings and methods for maintaining the drug coatings thereon 25 2003
7,060,709 Method of treating hepatic fibrosis 10 2004
7,806,924 Implantable structures for local vascular delivery of cladribine in combination with rapamycin for restenosis 2 2004
7,300,662 Drug/drug delivery systems for the prevention and treatment of vascular disease 8 2004
8,236,048 Drug/drug delivery systems for the prevention and treatment of vascular disease 0 2004
8,182,527 Heparin barrier coating for controlled drug release 0 2004
RE40418 Treatment of neoplasms with CCI-779/EKB-569 combination 0 2005
RE41084 Antineoplastic combinations 0 2006
RE41253 Antineoplastic combinations 0 2007
 
BOSTON SCIENTIFIC SCIMED, INC. (17)
6,515,009 Therapeutic inhibitor of vascular smooth muscle cells 55 1995
6,171,609 Therapeutic inhibitor of vascular smooth muscle cells 154 1995
6,306,421 Therapeutic inhibitor of vascular smooth muscle cells 73 1997
5,981,568 Therapeutic inhibitor of vascular smooth muscle cells 223 1997
6,358,989 Therapeutic inhibitor of vascular smooth muscle cells 45 1999
6,491,938 Therapeutic inhibitor of vascular smooth muscle cells 69 2001
8,067,022 Therapeutic inhibitor of vascular smooth muscle cells 0 2001
6,599,928 Therapeutic inhibitor of vascular smooth muscle cells 44 2001
6,569,441 Therapeutic inhibitor of vascular smooth muscle cells 54 2001
6,663,881 Therapeutic inhibitor of vascular smooth muscle cells 49 2001
6,908,622 Optimized dosing for drug coated stents 53 2002
6,720,350 Therapeutic inhibitor of vascular smooth muscle cells 37 2002
7,371,257 Stent lining 2 2004
7,906,133 Optimized dosing for drug coated stents 0 2005
7,625,410 Stent device and method 0 2006
8,158,670 Therapeutic inhibitor of vascular smooth muscle cells 0 2007
8,097,642 Therapeutic inhibitor of vascular smooth muscle cells 0 2007
 
CODMAN & SHURTLEFF, INC. (14)
6,673,106 Intravascular stent device 43 2002
7,001,422 Expandable stent and delivery system 21 2003
6,833,003 Expandable stent and delivery system 32 2003
7,195,648 Intravascular stent device 14 2003
6,955,685 Expandable stent with radiopaque markers and stent delivery system 65 2003
6,960,228 Intravascular stent device 5 2003
7,037,331 Intravascular stent device 33 2003
6,960,227 Expandable stent and delivery system 50 2004
7,201,769 Expandable stent and delivery system 13 2004
7,309,351 Expandable stent with markers and stent delivery system 15 2005
7,311,726 Intravascular stent device 8 2006
7,655,031 Stent delivery system with improved retraction member 0 2006
8,118,859 Occlusion device combination of stent and mesh having offset parallelogram porosity 0 2006
8,182,523 Stent delivery system with improved retraction member 0 2010
 
ABBOTT LABORATORIES (13)
7,455,853 Medical devices containing rapamycin analogs 1 2002
7,399,480 Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances using medical devices 3 2004
8,057,813 Multiple drug delivery from a balloon and a prosthesis 0 2005
8,257,724 Delivery of highly lipophilic agents via medical devices 0 2006
8,257,725 Delivery of highly lipophilic agents via medical devices 0 2006
8,257,726 Compositions, systems, kits, and methods of administering rapamycin analogs with paclitaxel using medical devices 0 2006
7,378,105 Drug delivery systems, kits, and methods for administering zotarolimus and paclitaxel to blood vessel lumens 8 2006
7,357,942 Compositions, systems, and kits for administering zotarolimus and paclitaxel to blood vessel lumens 6 2006
8,394,398 Methods of administering rapamycin analogs with anti-inflammatories using medical devices 0 2006
8,057,816 Compositions and methods of administering paclitaxel with other drugs using medical devices 0 2006
8,318,190 Method of treating disorders using compositions comprising zotarolimus and paclitaxel 0 2008
8,153,150 Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances for treatment of vascular disorder 0 2008
8,431,145 Multiple drug delivery from a balloon and a prosthesis 0 2009
 
LUTONIX, INC. (10)
8,414,909 Drug releasing coatings for medical devices 0 2007
8,414,525 Drug releasing coatings for medical devices 0 2008
8,425,459 Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent 0 2008
8,414,526 Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids 0 2008
8,430,055 Methods and apparatuses for coating balloon catheters 0 2009
8,414,910 Drug releasing coatings for medical devices 0 2010
8,403,910 Drug releasing coatings for medical devices 0 2011
8,404,300 Drug releasing coatings for medical devices 0 2011
8,366,660 Drug releasing coatings for medical devices 0 2011
8,366,662 Drug releasing coatings for medical devices 0 2011
 
INNOVATIONAL HOLDINGS LLC (9)
7,819,912 Expandable medical device with beneficial agent delivery mechanism 0 2003
7,896,912 Expandable medical device with S-shaped bridging elements 0 2004
7,517,362 Therapeutic agent delivery device with controlled therapeutic agent release rates 2 2004
8,187,321 Expandable medical device for delivery of beneficial agent 0 2005
7,850,727 Expandable medical device for delivery of beneficial agent 2 2005
7,842,083 Expandable medical device with improved spatial distribution 0 2006
7,850,728 Expandable medical device for delivery of beneficial agent 0 2006
8,052,734 Expandable medical device with beneficial agent delivery mechanism 0 2008
8,052,735 Expandable medical device with ductile hinges 0 2008
 
CORDIS CORPORATION (8)
6,585,764 Stent with therapeutically active dosage of rapamycin coated thereon 138 2001
6,818,013 Intravascular stent device 29 2002
6,808,536 Stent containing rapamycin or its analogs using a modified stent 46 2003
7,223,286 Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent 14 2004
7,914,573 Polymeric stent having modified molecular structures 0 2006
7,229,473 Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent 15 2006
7,217,286 Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent 8 2006
7,666,222 Methods and devices for delivering therapeutic agents to target vessels 4 2006
 
BIOSENSORS INTERNATIONAL GROUP, LTD. (7)
7,682,387 Drug-delivery endovascular stent and method for treating restenosis 0 2003
7,727,275 Drug-delivery endovascular stent and method of forming the same 15 2004
7,901,451 Drug-delivery endovascular stent and method for treating restenosis 0 2005
8,067,055 Drug-delivery endovascular stent and method of use 0 2007
8,252,046 Drug-delivery endovascular stent and method for treating restenosis 0 2009
8,308,795 Drug-delivery endovascular stent and method of forming the same 0 2010
8,252,047 Drug-delivery endovascular stent and method for treating restenosis 0 2011
 
AVANTEC VASCULAR CORPORATION (5)
7,018,405 Intravascular delivery of methylprednisolone 4 2001
6,471,980 Intravascular delivery of mycophenolic acid 114 2001
7,077,859 Apparatus and methods for variably controlled substance delivery from implanted prostheses 70 2001
7,083,642 Delivery of therapeutic capable agents 43 2002
6,858,221 Intravascular delivery of mycophenolic acid 5 2002
 
ARIAD PHARMACEUTICALS, INC. (4)
7,091,213 Phosphorus-containing compounds and uses thereof 5 2004
7,186,826 Phosphorus-containing compounds and uses thereof 3 2006
7,709,020 Implantable device comprising phosphorus-containing macrolides 1 2007
8,058,426 Phosphorus-containing compounds and uses thereof 0 2010
 
ICON INTERVENTIONAL SYSTEMS, INC. (4)
8,016,881 Sutures and surgical staples for anastamoses, wound closures, and surgical closures 1 2004
8,070,796 Thrombosis inhibiting graft 0 2005
7,967,855 Coated medical device 1 2005
8,114,152 Stent coating 0 2008
 
ICON MEDICAL CORP. (4)
7,211,108 Vascular grafts with amphiphilic block copolymer coatings 6 2004
7,488,444 Metal alloys for medical devices 1 2006
8,323,333 Fragile structure protective coating 0 2006
8,100,963 Biodegradable device 0 2006
 
GP MEDICAL, INC. (3)
6,624,138 Drug-loaded biological material chemically treated with genipin 24 2002
7,282,220 Genipin-crosslinked gelatin microspheres as drug carrier 0 2003
7,351,421 Drug-eluting stent having collagen drug carrier chemically treated with genipin 7 2004
 
PONIARD PHARMACEUTICALS, INC. (3)
6,197,789 Prevention and treatment of cardiovascular pathologies with tamoxifen analogues 19 1997
6,251,920 Prevention and treatment of cardiovascular pathologies 15 1998
6,262,079 Prevention and treatment of cardiovascular pathologies 16 1999
 
SANTEN PHARMACEUTICAL CO., LTD. (3)
7,585,517 Transscleral delivery 3 2004
8,222,271 Formulations and methods for vascular permeability-related diseases or conditions 0 2007
8,367,097 Liquid formulations for treatment of diseases or conditions 0 2010
 
WYETH LLC (3)
8,026,276 Parenteral CCI-779 formulations containing cosolvents, an antioxidant, and a surfactant 1 2003
7,781,446 Use of CCI-779 as an antineoplastic agent 0 2007
8,299,116 CCI-779 concentrate formulations 0 2011
 
480 BIOMEDICAL, INC. (2)
8,372,133 Polymeric implant delivery system 0 2009
8,137,396 Medical implant 0 2010
 
SCIMED LIFE SYSTEMS, INC. (2)
6,899,731 Controlled delivery of therapeutic agents by insertable medical devices 100 2001
6,890,339 Stent lining 28 2002
 
VASCULAR THERAPIES, LLC (2)
6,726,923 Apparatus and methods for preventing or treating failure of hemodialysis vascular access and other vascular grafts 45 2002
7,807,191 Apparatus and methods for preventing or treating failure of hemodialysis vascular access and other vascular grafts 0 2004
 
ADVANCED CARDIOVASCULAR SYSTEMS, INC. (1)
8,303,651 Polymeric coating for reducing the rate of release of a therapeutic substance from a stent 0 2001
 
ANGIOTECH PHARMACEUTICALS, INC. (1)
6,534,693 Surgically implanted devices having reduced scar tissue formation 41 2001
 
ATRIUM MEDICAL CORPORATION (1)
6,923,927 Method for forming expandable polymers having drugs or agents included therewith 1 2004
 
AVANTAC VASCULAR CORPORATION (1)
6,939,375 Apparatus and methods for controlled substance delivery from implanted prostheses 6 2001
 
AVI BIOPHARMA, INC. (1)
7,754,238 Delivery of microparticle-conjugated drugs for inhibition of stenosis 0 2002
 
BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (1)
7,311,727 Encased stent 40 2004
 
CID S.P.A. (1)
7,946,019 Process for producing a stent for angioplasty 0 2010
 
ELATA PLC (1)
6,384,046 Use of 40-O-(2-hydroxy)ethylrapamycin for treatment of restenosis and other disorders 16 2000
 
MED INSTITUTE, INC. (1)
7,445,628 Method of treating a patient with a coated implantable medical device 8 2003
 
MEDLOGICS DEVICE CORPORATION (1)
8,097,269 Bioactive material delivery systems comprising sol-gel compositions 0 2006
 
SCIOS INC. (1)
7,244,441 Stents and intra-luminal prostheses containing map kinase inhibitors 2 2004
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (1)
7,981,441 Drug delivery systems using mesoporous oxide films 7 2004
 
VASCULAR CONCEPTS HOLDINGS LIMITED (1)
6,641,611 Therapeutic coating for an intravascular implant 83 2001
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (3)
7,226,473 Treatment of stenotic regions 5 2003
7,468,052 Treatment of stenotic regions 0 2007
8,439,968 Expandable medical device for delivery of beneficial agent 0 2011