Oxa- or azasteroid derivatives
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United States of America Patent
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May 21, 1996
Grant Date -
N/A
app pub date -
Sep 28, 1993
filing date -
Mar 28, 1991
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Compounds are described having the formula ##STR1## wherein A denotes C.dbd.O, CH.sub.2, C.dbd.CH.sub.2 or C.dbd.CH-lower alkyl; B denotes O, NH or N-lower alkyl; X does not exist, or denotes C.dbd.O or CH.sub.2 ; n denotes 2 or 3 when X does not exist, or denotes 1 or 2 when X denotes C.dbd.O or CH.sub.2 ; and the broken line between the 1- and 2-positions of the steroid skeleton means that a double bond may optionally exist there. These compounds have an aromatase inhibition action and are useful for prophylaxis or treatment of diseases caused by excess of estrogens, for example, breast cancer, uterine cancer, prostatic hypertrophy, etc.
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