Antiprogestin cyclophasic hormonal regimen
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United States of America Patent
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May 28, 1996
Grant Date -
N/A
app pub date -
Dec 19, 1994
filing date -
Dec 19, 1994
priority date (Note) -
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status (Latency Note)
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Abstract
The present invention is directed to cyclophasic hormonal regimens which comprise antiprogestin and progestin for human contraception whereby progestin is administered in the alternating presence and absence of an antiprogestin in effective amounts to upregulate steroid receptor levels or is alternatively dosed with effective amounts of antiprogestin to upregulate steroid receptor levels. The present invention also provides an estrogen containing cyclophasic hormonal regimen for climacteric or menopausal hormone replacement therapy comprising the administration of an effective hormone replacement amount of estrogen in alternating doses with a combined amount of estrogen and an effective amount of antiprogestin to inhibit proliferation of endometrial tissue caused by the administration of the estrogen.
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