Use of restriction endonucleases against viruses, including HIV
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United States of America Patent
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Jun 4, 1996
Issued Date -
N/A
app pub date -
Jun 8, 1994
filing date -
Apr 2, 1992
priority date (Note) -
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Abstract
Restriction endonucleases are administered to a patient topically or internally to prevent or ameliorate viral infection. The endonucleases are also useful to treat products, such as blood and blood derived products, to eliminate viral transmission when the products are administered to a patient. In addition, the endonucleases may be used in the manner of a disinfectant to inactivate viral contamination on objects. The endonucleases are used in their native form, modified to provide decreased immunoreactivity or increased ability to target a site of infection or both, and alone or in combination with a suitable excipient. In addition to methods of treatment and disinfection, the invention provides related products, such as pharmaceutical compositions.
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