N-methyldeacetylcolchiceinamide derivatives
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United States of America Patent
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Jun 4, 1996
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app pub date -
Jan 3, 1995
filing date -
Jan 20, 1993
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Abstract
N-methyldeacetylcolchiceinamide derivatives represented by the formula ##STR1## wherein R denotes a residue obtained by removing COOH from a C.sub.3 -C.sub.7 sugar carboxylic acid, and hydroxyl groups present in the residue may properly be protected with a protecting group for a hydroxyl group. The N-methyldeacetylcolchiceinamide derivatives have less toxicity and strong effect for inhibiting proliferation of tumor cells, and are expected to be used as a carcinostatic.
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