Thermal cycler including a temperature gradient block

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United States of America Patent

PATENT NO 5525300
SERIAL NO

08139540

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A method in which a temperature gradient is generated across a 'gradient' block, and an apparatus comprising a block across which a temperature gradient can be generated. By setting up such a gradient, multiple reaction mixtures held in wells on the gradient block can be simultaneously run at temperatures which differ only slightly, thereby permitting an optimum temperature for the reaction to be quickly identified. In a preferred embodiment the gradient block is integrated into a thermal cycler used for nucleic acid amplification reactions.

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Patent Owner(s)

  • AGILENT TECHNOLOGIES, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Danssaert, John L San Diego, CA 1 237
Shoemaker, Daniel D Stanford, CA 22 1096
Shopes, Robert J San Diego, CA 7 266

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