In a preferred embodiment, a multiple sample transfer device which includes a plurality of hollow pistons disposed in a like number of cylindrical channels and connected to a moving plate to permit simultaneous movement of the pistons. At the lower end of each channel is a removable pipette tip. An apparatus is provided to bring a multiwell sample tray into operating engagement with the pipette tips. Flexible tubes are attached between the upper ends of the hollow pistons and a liquid reservoir. Clamping devices are provided to permit the selective pinching or opening of the tubes. When the tubes are pinched, the pistons can be used in either liquid-back-filled or air displacement modes to aspirate and dispense liquids from and to the sample tray. When the tubes are selectively sequentially pinched or open, aspiration and dispensing can be controlled by the timing of the pinching and the provision of vacuum or pressure in the liquid reservoir. All operations, including mounting and removal of the pipette tips, can be automatically controlled through use of a programmable computer.
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