Isolated components of dense microspheres derived from mammalian brain tissue and antibodies thereto
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United States of America Patent
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Jun 11, 1996
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N/A
app pub date -
Dec 17, 1993
filing date -
Aug 27, 1986
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Expired
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Abstract
DMS present in the brain of individuals susceptible to cerebral amyloidosis disintegrate into DMS components to form cerebral amyloid plaques and other DMS components that are removed from the brain via circulating bodily fluids. Detecting the presence of these removed DMS components in circulating bodily fluids provides a diagnostic mechanism to determine the onset of cerebral amyloid plaque formation. Antibodies also can be raised against isolated DMS components and subsequently utilized in a diagnostic method capable of detecting the onset of cerebral amyloid plaque formation.
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