Oligonucleotide-polyamide conjugates and methods of production and applications of the same
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United States of America Patent
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Jun 11, 1996
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Jan 3, 1995
filing date -
Oct 28, 1987
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Abstract
Oligonucleotide-polyamide conjugates of the formula X--L--Y, where X is a polyamide, Y is an oligonucleotide, and L is a linker which forms a covalent bond with the amino-terminus of the polyamide X and the 3' phosphate group of the oligonucleotide Y. Conjugates may be synthesized by assembling a polyamide on a solid support matrix, adding a suitable linker molecule, followed by synthesis of the oligonucleotide. Methods for detecting specific polynucleotides with oligonucleotide-polyamide conjugates are also described.
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