Detection of loss of the wild-type P53 gene and kits therefor
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United States of America Patent
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Jun 18, 1996
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Mar 22, 1993
filing date -
Mar 29, 1989
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Abstract
Methods and kits are provided for assessing mutations and/or loss of the p53 gene in human tumors. Both deletion mutations and point mutations in p53 are observed in the same human tumor cells and these mutations are clonal within the cells of the tumor. Loss of wild-type p53 genes is responsible for neoplastic progression.
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