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Abstract

Sensor devices comprising enzyme electrodes incorporating a microporous membrane coated with the carbonaceous material known as 'diamond-like carbon' (most conveniently deposited by decomposition of a hydrocarbon, induced by radiation or a high electric field). The membrane material is preferably a polycarbonate and its thickness preferably less than 10 microns, and the coating is preferably 0.01 to 5 .mu.m thick. The preferred porosity is provided by pores of the order of 0.05 to 0.01 microns. The coated membrane imparts high resistance to fouling by contact with whole blood, extends the linearity of the electrode response over a substantially greater range, e.g. in the analytical determination of glucose in blood, and combines a high degree of restriction to passage of interferents while retaining high permeability to hydrogen peroxide and oxygen. Most conveniently used for amperometric measurements, especially using a Clark electrode pair, with an 'active' anode of platinum.

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First Claim