Vivo dosimeter for photodynamic therapy
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United States of America Patent
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Jul 9, 1996
Issued Date -
N/A
app pub date -
Jan 27, 1994
filing date -
Oct 31, 1991
priority date (Note) -
Expired
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Abstract
A device for measuring the fluorescence generated by photoactivated molecules during photodynamic therapy (PDT) and a method of using the device for dosimetry. The device, which comprises an isotropic spherical probe and detector electronics, simultaneously measures the space irradiance and time-integrated fluorescence during PDT. It is shown that there is a correlation between the time-integrated fluorescence generated during PDT treatment of a tumor and the delay in the regrowth of the tumor. The device provides the simultaneous measurement of the space irradiance and integrated fluorescence which measurements enable real time dosimetry during PDT.
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