US Patent No: 5,534,028

Number of patents in Portfolio can not be more than 2000

Hydrogel intervertebral disc nucleus with diminished lateral bulging

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Abstract

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A prosthetic nucleus for a vertebral disc is made of a hydrogel material. The hydrogel prosthetic nucleus has a shape generally conforming to the natural nucleus pulposus, and it exhibits diminished lateral bulging under high compressive loads. The hydrogel has a water content of from 30% to 90% and has a compressive strength of 4 MNm.sup.-2 or greater. When the hydrogel material is dehydrated, it has a dimension of less than half of that of the hydrated hydrogel nucleus. The prosthetic nucleus may be formed of two or more pieces of hydrogel material which pieces, when combined, have a shape generally conforming to the natural nucleus. The prosthetic nucleus may have a stiff posterior periphery and/or a thickened anterior wall.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
HOWMEDICA OSTEONICS CORP.MAHWAH, NJ495
PFIZER INC.NEW YORK, NY3328

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bao, Qi-Bin Bloomington, MN 50 3565
Higham, Paul A Ringwood, NJ 15 2561

Cited Art Landscape

Patent Info (Count) # Cites Year
 
RAY MEDICA, INC. (2)
4,772,287 Prosthetic disc and method of implanting 675 1987
4,904,260 Prosthetic disc containing therapeutic material 555 1988
 
HOWMEDICA OSTEONICS CORP. (1)
5,047,055 Hydrogel intervertebral disc nucleus 596 1990
 
LIFESHIELD SCIENCES LLC (1)
2004/0158,312 Braided endoluminal device having tapered filaments 4 2003
 
PFIZER HOSPITAL PRODUCTS GROUP, INC. (1)
4,714,469 Spinal implant 530 1987
 
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY (1)
4,911,718 Functional and biocompatible intervertebral disc spacer 485 1988
 
ZIMMER GMBH (1)
4,932,969 Joint endoprosthesis 354 1987
 
Other [Check patent profile for assignment information] (3)
4,349,921 Intervertebral disc prosthesis 853 1980
4,309,777 Artificial intervertebral disc 654 1980
4,863,477 Synthetic intervertebral disc prosthesis 525 1987

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
KYPHON SARL (68)
6,500,178 Spine distraction implant and method 231 1999
6,379,355 Spine distraction implant and method 138 1999
6,332,882 Spine distraction implant 129 1999
7,621,950 Expandable intervertebral spacer 73 2000
6,746,485 Hair used as a biologic disk, replacement, and/or structure and method 56 2000
6,419,676 Spine distraction implant and method 168 2000
6,451,020 Spine distraction implant and method 147 2000
6,419,677 Spine distraction implant and method 155 2001
6,796,983 Spine distraction implant and method 142 2001
7,101,375 Spine distraction implant 157 2001
6,902,566 Spinal implants, insertion instruments, and methods of use 90 2001
6,514,256 Spine distraction implant and method 235 2001
6,478,796 Spin distraction implant and method 181 2001
6,582,433 Spine fixation device and method 294 2001
7,201,751 Supplemental spine fixation device 194 2001
6,699,246 Spine distraction implant 239 2001
6,699,247 Spine distraction implant 144 2001
6,926,728 Curved dilator and method 134 2001
6,652,534 Apparatus and method for determining implant size 114 2001
6,712,819 Mating insertion instruments for spinal implants and methods of use 188 2001
6,652,527 Supplemental spine fixation device and method 171 2001
6,695,842 Interspinous process distraction system and method with positionable wing and method 260 2001
7,189,234 Interspinous process implant sizer and distractor with a split head and size indicator and method 47 2001
7,029,473 Deflectable spacer for use as an interspinous process implant and method 43 2002
7,833,246 Interspinous process and sacrum implant and method 0 2003
7,497,859 Tools for implanting an artificial vertebral disk 11 2003
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7,273,496 Artificial vertebral disk replacement implant with crossbar spacer and method 52 2003
7,083,649 Artificial vertebral disk replacement implant with translating pivot point 107 2003
6,966,929 Artificial vertebral disk replacement implant with a spacer 98 2003
7,217,291 System and method for replacing degenerated spinal disks 76 2003
7,335,203 System and method for immobilizing adjacent spinous processes 133 2004
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7,452,379 Artificial vertebral disk replacement implant with crossbar spacer and method 1 2004
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7,691,146 Method of laterally inserting an artificial vertebral disk replacement implant with curved spacer 15 2004
7,670,377 Laterally insertable artifical vertebral disk replacement implant with curved spacer 15 2004
7,520,899 Laterally insertable artificial vertebral disk replacement implant with crossbar spacer 17 2004
7,503,935 Method of laterally inserting an artificial vertebral disk replacement with translating pivot point 26 2004
7,320,707 Method of laterally inserting an artificial vertebral disk replacement implant with crossbar spacer 49 2004
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7,575,600 Artificial vertebral disk replacement implant with translating articulation contact surface and method 28 2004
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7,601,170 Inter-cervical facet implant and method 30 2005
7,591,851 Inter-cervical facet implant and method 33 2005
7,955,356 Laterally insertable interspinous process implant 2 2005
7,918,877 Lateral insertion method for spinous process spacer with deployable member 1 2005
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8,100,944 Inter-cervical facet implant and method for preserving the tissues surrounding the facet joint 4 2005
7,909,853 Interspinous process implant including a binder and method of implantation 5 2005
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7,828,822 Spinous process implant 10 2006
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7,476,251 Interspinous process apparatus and method with a selectably expandable spacer 29 2006
7,803,190 Interspinous process apparatus and method with a selectably expandable spacer 4 2006
8,012,209 Interspinous process implant including a binder, binder aligner and method of implantation 0 2007
7,635,378 Spine distraction implant and method 20 2007
 
GMEDELAWARE 2 LLC (59)
6,974,478 Prostheses, systems and methods for replacement of natural facet joints with artificial facet joint surfaces 151 2002
6,902,580 Prosthesis for the replacement of a posterior element of a vertebra 140 2002
7,074,237 Multiple facet joint replacement 128 2003
7,041,136 Facet joint replacement 181 2003
7,074,238 Prostheses, tools and methods for replacement of natural facet joints with artificial facet joint surfaces 45 2003
8,163,017 Facet arthroplasty devices and methods 0 2003
8,092,532 Facet arthroplasty devices and methods 0 2003
8,070,811 Facet arthroplasty devices and methods 0 2003
8,066,771 Facet arthroplasty devices and methods 0 2003
7,087,084 Method for replacing a natural facet joint with a prosthesis having an artificial facet joint structure 129 2003
8,187,303 Anti-rotation fixation element for spinal prostheses 0 2004
7,051,451 Facet joint prosthesis measurement and implant tools 132 2004
8,419,770 Spinal facet implants with mating articulating bearing surface and methods of use 0 2004
7,753,937 Linked bilateral spinal facet implants and methods of use 12 2004
7,588,590 Spinal facet implant with spherical implant apposition surface and bone bed and methods of use 9 2004
7,691,145 Prostheses, systems and methods for replacement of natural facet joints with artificial facet joint surfaces 13 2004
7,608,104 Prostheses, tools and methods for replacement of natural facet joints with artifical facet joint surfaces 6 2004
7,588,578 Surgical measurement systems and methods 2 2004
7,507,242 Surgical measurement and resection framework 5 2004
7,993,373 Polyaxial orthopedic fastening apparatus 5 2005
7,674,293 Crossbar spinal prosthesis having a modular design and related implantation methods 30 2005
7,722,647 Apparatus and method for posterior vertebral stabilization 2 2005
7,566,345 Prosthesis for the replacement of a posterior element of a vertebra 9 2005
7,445,635 Method and apparatus for spine joint replacement 35 2005
8,398,681 Adjacent level facet arthroplasty devices, spine stabilization systems, and methods 1 2005
8,313,511 Facet joint replacement 0 2005
7,618,453 Facet joint replacement 7 2005
7,406,775 Implantable orthopedic device component selection instrument and methods 38 2005
8,066,740 Facet joint prostheses 0 2005
8,221,461 Crossbar spinal prosthesis having a modular design and systems for treating spinal pathologies 0 2005
8,062,336 Polyaxial orthopedic fastening apparatus with independent locking modes 5 2005
8,523,907 Prostheses, tools and methods for replacement of natural facet joints with artificial facet joint surfaces 0 2006
7,608,106 Facet arthroplasty devices and methods 7 2006
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7,290,347 Facet joint prosthesis measurement and implant tools 26 2006
8,231,655 Prostheses and methods for replacement of natural facet joints with artificial facet joint surfaces 1 2006
8,562,649 System and method for multiple level facet joint arthroplasty and fusion 0 2006
7,914,556 Arthroplasty revision system and method 0 2006
8,579,941 Linked bilateral spinal facet implants and methods of use 0 2007
7,621,955 Facet joint replacement 7 2007
8,496,686 Minimally invasive spine restoration systems, devices, methods and kits 0 2007
8,702,755 Angled washer polyaxial connection for dynamic spine prosthesis 0 2007
8,491,635 Crossbar spinal prosthesis having a modular design and related implantation methods 0 2007
8,425,557 Crossbar spinal prosthesis having a modular design and related implantation methods 1 2007
8,496,687 Crossbar spinal prosthesis having a modular design and related implantation methods 0 2007
8,353,933 Facet joint replacement 0 2008
8,333,789 Facet joint replacement 0 2008
8,409,254 Prostheses, tools and methods for replacement of natural facet joints with artificial facet joint surfaces 0 2008
8,675,930 Implantable orthopedic device component selection instrument and methods 0 2008
8,702,759 System and method for bone anchorage 0 2008
8,308,768 System and method for facet joint replacement 0 2008
8,252,027 System and method for facet joint replacement 0 2008
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8,777,994 System and method for multiple level facet joint arthroplasty and fusion 0 2008
7,998,177 Linked bilateral spinal facet implants and methods of use 5 2008
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7,815,648 Surgical measurement systems and methods 0 2008
 
WARSAW ORTHOPEDIC, INC. (51)
6,547,823 Intervertebral implant 74 1999
6,277,149 Ramp-shaped intervertebral implant 256 1999
7,147,665 Threaded cylindrical multidiscoid single or multiple array disc prosthesis 69 1999
6,764,514 Prosthetic apparatus and method 86 2000
6,402,785 Artificial disc implant 246 2000
6,620,196 Intervertebral disc nucleus implants and methods 165 2000
6,733,531 Anchoring devices and implants for intervertebral disc augmentation 165 2000
6,613,089 Laterally expanding intervertebral fusion device 32 2000
RE42576 Human spinal disc prosthesis 0 2001
6,949,105 Method and apparatus for stereotactic implantation 28 2001
7,641,692 Implantable joint prosthesis 7 2001
6,562,045 Machining apparatus 21 2001
6,706,067 Spinal intervertebral implant and method of making 59 2001
6,733,505 Apparatus and method for loading a prosthetic nucleus into a deployment cannula to replace the nucleus pulposus of an intervertebral disc 13 2001
RE42480 Human spinal disc prothesis with hinges 2 2001
7,503,933 Lordotic interbody spinal fusion implants 53 2002
7,025,787 Implantable joint prosthesis and associated instrumentation 92 2002
7,081,120 Instrumentation and method for delivering an implant into a vertebral space 129 2002
6,911,045 Bio-implant insertion instrument 18 2003
6,974,479 System and method for blocking and/or retaining a prosthetic spinal implant 74 2003
7,601,174 Wear-resistant endoprosthetic devices 11 2003
7,828,845 Laterally expanding intervertebral fusion device 13 2003
7,662,185 Intervertebral implants 4 2003
7,204,851 Method and apparatus for delivering an intervertebral disc implant 37 2003
7,179,262 Method and apparatus for stereotactic implantation 3 2003
7,789,914 Implant having arcuate upper and lower bearing surfaces along a longitudinal axis 16 2004
7,618,461 Composite intervertebral disc implants and methods for forming the same 18 2004
7,503,936 Methods for forming and retaining intervertebral disc implants 23 2004
7,726,002 Processes for making spinal intervertebral implant, interconnections for such implant 0 2004
8,728,160 Expandable intervertebral spacer 0 2005
8,333,985 Non-glycerol stabilized bone graft 0 2005
7,780,708 Implant retaining device 5 2005
7,776,090 Inter-cervical facet implant and method 36 2005
7,763,078 Spinal device including lateral approach 14 2005
7,749,269 Spinal system and method including lateral approach 17 2005
7,763,050 Inter-cervical facet implant with locking screw and method 21 2005
7,520,900 Intervertebral disc nucleus implants and methods 9 2005
8,066,749 Implant for stabilizing a bone graft during spinal fusion 5 2005
8,480,744 Method of preparing an implant for delivery into a vertebral space 0 2006
8,066,750 Port structures for non-rigid bone plates 0 2006
7,857,818 Method and apparatus for delivering an intervertebral disc implant 2 2007
7,837,734 System and method for replacing degenerated spinal disks 30 2007
7,776,095 Spinal system and method including lateral approach 16 2007
8,092,541 Method of using an anti-growth matrix as a barrier for cell attachment and osteo-inductive factors 3 2007
8,372,157 Joint revision implant 0 2008
8,092,542 Implantable joint prosthesis 2 2009
7,988,734 Spinal system and method including lateral approach 1 2010
8,672,980 Implant retaining device 0 2010
8,021,430 Anatomic spinal implant having anatomic bearing surfaces 34 2010
8,425,530 Apparatus for sizing a facet joint 0 2011
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INTRINSIC THERAPEUTICS, INC. (32)
6,482,235 Devices and methods of vertebral disc augmentation 211 2000
7,220,281 Implant for reinforcing and annulus fibrosis 59 2002
7,094,258 Methods of reinforcing an annulus fibrosis 45 2002
6,883,520 Methods and apparatus for dynamically stable spinal implant 140 2002
7,124,761 Deployment devices and methods for vertebral disc augmentation 44 2002
7,717,961 Apparatus delivery in an intervertebral disc 21 2003
7,507,243 Devices and method for augmenting a vertebral disc 25 2003
7,563,282 Method of supporting nucleus pulposus 24 2003
7,727,241 Device for delivering an implant through an annular defect in an intervertebral disc 16 2004
8,002,836 Method for the treatment of the intervertebral disc anulus 0 2004
7,749,275 Method of reducing spinal implant migration 18 2004
7,513,911 Method of implanting dynamically stable spinal implant 46 2004
7,553,329 Stabilized intervertebral disc barrier 50 2004
7,658,765 Resilient intervertebral disc implant 17 2004
8,231,678 Method of treating a herniated disc 3 2006
7,879,097 Method of performing a procedure within a disc 18 2006
7,524,333 Method of anchoring an implant in an intervertebral disc 33 2006
7,500,978 Method for delivering and positioning implants in the intervertebral disc environment 21 2006
7,553,330 Methods of reinforcing an intervertebral disc annulus 25 2006
7,998,213 Intervertebral disc herniation repair 8 2006
7,972,337 Devices and methods for bone anchoring 13 2006
7,959,679 Intervertebral anulus and nucleus augmentation 9 2007
7,867,278 Intervertebral disc anulus implant 17 2008
8,025,698 Method of rehabilitating an anulus fibrosus 8 2009
8,021,425 Versatile method of repairing an intervertebral disc 9 2009
8,454,612 Method for vertebral endplate reconstruction 0 2009
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8,323,341 Impaction grafting for vertebral fusion 0 2009
8,361,155 Soft tissue impaction methods 0 2010
8,409,284 Methods of repairing herniated segments in the disc 1 2011
8,257,437 Methods of intervertebral disc augmentation 4 2011
8,394,146 Vertebral anchoring methods 0 2011
 
ANULEX TECHNOLOGIES, INC. (31)
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7,004,970 Methods and devices for spinal disc annulus reconstruction and repair 88 2002
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6,805,695 Devices and methods for annular repair of intervertebral discs 222 2003
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6,997,956 Spinal disc annulus reconstruction method and spinal disc annulus stent 31 2003
7,753,941 Devices and methods for annular repair of intervertebral discs 18 2004
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7,828,850 Methods and devices for spinal disc annulus reconstruction and repair 38 2006
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7,985,257 Methods and devices for spinal disc annulus reconstruction and repair 4 2006
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7,993,405 Spinal disc annulus repair system and methods 3 2006
7,951,201 Method and apparatus for the treatment of the intervertebral disc annulus 4 2007
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8,128,698 Method and apparatus for the treatment of the intervertebral disc annulus 2 2008
8,163,022 Method and apparatus for the treatment of the intervertebral disc annulus 2 2009
8,652,153 Intervertebral disc annulus repair system and bone anchor delivery tool 0 2010
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8,556,977 Tissue anchoring system and method 0 2010
8,454,697 Method and apparatus for the treatment of tissue 0 2012
 
FLEXUSPINE, INC. (24)
7,909,869 Artificial spinal unit assemblies 20 2004
8,753,398 Method of inserting an expandable intervertebral implant without overdistraction 0 2005
8,257,440 Method of insertion of an expandable intervertebral implant 7 2005
8,172,903 Expandable intervertebral implant with spacer 9 2005
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8,123,810 Expandable intervertebral implant with wedged expansion member 14 2005
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8,118,871 Expandable articulating intervertebral implant 14 2005
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8,052,723 Dynamic posterior stabilization systems and methods of use 18 2006
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8,597,358 Dynamic interbody devices 1 2007
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8,162,994 Posterior stabilization system with isolated, dual dampener systems 3 2007
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ANOVA CORP. (13)
6,419,704 Artificial intervertebral disc replacement methods and apparatus 411 1999
6,454,804 Engineered tissue annulus fibrosis augmentation methods and apparatus 91 2000
6,969,404 Annulus fibrosis augmentation methods and apparatus 99 2002
6,793,677 Method of providing cells and other biologic materials for transplantation 34 2002
6,755,863 Rotator cuff repair using engineered tissues 12 2002
6,648,919 Transplantation of engineered meniscus tissue to the intervertebral disc 57 2002
6,648,920 Natural and synthetic supplements to engineered annulus and disc tissues 65 2002
7,201,774 Artificial intervertebral disc replacements incorporating reinforced wall sections 17 2003
6,875,235 Prosthetic joints with contained compressible resilient members 30 2003
7,273,497 Methods for treating a defect in the annulus fibrosis 29 2003
7,435,260 Use of morphogenetic proteins to treat human disc disease 24 2004
7,060,100 Artificial disc and joint replacements with modular cushioning components 21 2004
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7,645,301 Devices and methods for disc replacement 10 2006
7,534,268 Devices and methods for disc replacement 24 2006
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D566842 Spinal implant 4 2007
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GEORGIA TECH RESEARCH CORPORATION (6)
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7,910,124 Load bearing biocompatible device 4 2005
8,142,808 Method of treating joints with hydrogel implants 2 2008
7,682,540 Method of making hydrogel implants 19 2008
8,318,192 Method of making load bearing hydrogel implants 1 2008
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HOWMEDICA OSTEONICS CORP. (6)
5,976,186 Hydrogel intervertebral disc nucleus 442 1996
6,280,475 Hydrogel intervertebral disc nucleus implantation method 146 1999
6,783,721 Method of making an ion treated hydrogel 12 2001
7,282,165 Wear resistant hydrogel for bearing applications 11 2004
7,332,117 Ion treated hydrogel 6 2004
8,197,547 Radiovisible hydrogel intervertebral disc nucleus 0 2005
 
NUVASIVE, INC. (6)
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8,167,915 Methods and apparatus for treating spinal stenosis 1 2006
7,946,236 Using zigzags to create three-dimensional embroidered structures 13 2007
7,942,104 3-dimensional embroidery structures via tension shaping 2 2007
8,282,681 Bioresorbable spinal implant and related methods 0 2008
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DISC DYNAMICS, INC. (5)
6,224,630 Implantable tissue repair device 362 1998
7,077,865 Method of making an intervertebral disc prosthesis 72 2003
7,001,431 Intervertebral disc prosthesis 128 2003
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ORTHO DEVELOPMENT CORPORATION (5)
6,579,318 Intervertebral spacer 136 2000
6,852,127 Method of implanting an intervertebral spacer 14 2002
D501555 Implant 29 2003
D494274 Implant 30 2003
D493225 Implant 32 2003
 
REPLICATION MEDICAL, INC. (5)
6,264,695 Spinal nucleus implant 243 1999
6,726,721 Hydrogel-based prosthetic device for replaceing at least a part of the nucleus of a spinal disc 87 2001
RE42837 Spinal nucleus implant 3 2003
7,204,897 Hydrogel-based prosthetic device for replacing at least a part of the nucleus of a spinal disc 7 2004
7,806,934 Radially compressed dehydrated spinal nucleus implants 1 2005
 
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8,740,949 Methods and apparatus for stabilizing bone 0 2011
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TRANS1 INC. (5)
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7,547,324 Spinal mobility preservation apparatus having an expandable membrane 48 2004
7,491,236 Dual anchor prosthetic nucleus apparatus 55 2004
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MEDICINELODGE, INC. (4)
6,579,319 Facet joint replacement 266 2000
6,565,605 Multiple facet joint replacement 301 2000
6,419,703 Prosthesis for the replacement of a posterior element of a vertebra 294 2001
7,090,698 Method and apparatus for spine joint replacement 154 2002
 
P TECH, LLC. (4)
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8,617,208 Method of using ultrasonic vibration to secure body tissue with fastening element 0 2006
8,617,185 Fixation device 0 2008
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RAYMEDICA, LLC (4)
6,022,376 Percutaneous prosthetic spinal disc nucleus and method of manufacture 386 1998
6,602,291 Prosthetic spinal disc nucleus having a shape change characteristic 95 1999
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GLOBUS MEDICAL, INC. (3)
7,674,296 Expandable vertebral prosthesis 25 2005
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KERAPLAST TECHNOLOGIES, LTD. (3)
6,379,690 Keratin-based hydrogel for biomedical applications and method of production 18 2000
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PIONEER SURGICAL TECHNOLOGY, INC. (3)
7,001,433 Artificial intervertebral disc device 32 2002
8,241,360 Artificial disc device 1 2004
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ARTICULINX, INC. (2)
8,292,954 Disc-based orthopedic devices 1 2010
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BAXANO SURGICAL, INC. (2)
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Collabcom II, LLC (2)
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K2M, INC. (2)
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OSTEOTECH, INC. (2)
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SDGI HOLDINGS, INC. (2)
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STRYKER SPINE (2)
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (2)
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7,641,691 Biodegradable/bioactive nucleus pulposus implant and method for treating degenerated intervertebral discs 3 2006
 
Transl, Inc. (2)
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Bridport-Gundry PLC c/o Pearsalls Implants (1)
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CAUTHEN RESEARCH GROUP, INC. (1)
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CORTEK SPINE, INC. (1)
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DEPUY SPINE, INC. (1)
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DREXEL UNIVERSITY (1)
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GME Delaware 2 LLC (1)
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GORENSEK, BOGOMIR, MR (1)
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LAWSON, KEVIN J., AN INDIVIDUAL (1)
6,146,422 Prosthetic nucleus replacement for surgical reconstruction of intervertebral discs and treatment method 177 1999
 
Loop Telecommunication International, Inc. (1)
6,132,465 Tapered prosthetic spinal disc nucleus 319 1998
 
NAXCOR (1)
6,342,074 Anterior lumbar interbody fusion implant and method for fusing adjacent vertebrae 124 2000
 
Pioneer Signal Technology, Inc. (1)
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QUEEN'S UNIVERSITY AT KINGSTON (1)
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RIVERBEND DESIGN LLC (1)
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SPINADYNE, INC. (1)
D598105 Convex intervertebral disc prosthesis 1 2008
 
SPINAL CONCEPTS, INC. (1)
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SPINE WAVE, INC. (1)
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SPINEMEDICA, LLC (1)
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SpinLabs, LLC (1)
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SYNTHES USA, LLC (1)
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VALVE HOLDINGS, L.L.C. (1)
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X-SPINE SYSTEMS, INC. (1)
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Other [Check patent profile for assignment information] (4)
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8,157,865 Apparatus and method for stabilizing adjacent bone portions 0 2010
8,647,386 Expandable intervertebral implant system and method 1 2010
8,764,835 Intervertebral disc treatment methods and apparatus 0 2011

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