Pharmaceutical granulated composition and method for preparing same
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United States of America Patent
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-
Jul 9, 1996
Grant Date -
N/A
app pub date -
Sep 10, 1993
filing date -
Jan 10, 1992
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A granulated composition for direct tableting, comprising non-pressed or difficulty pressed, water-soluble, crystalline pharmaceutical substances, binder, lubricant and water, contains at least 98 wt. % of a pharmaceutically active component. The tablets manufactured from said composition have high hardness and the controllable time of dissolution. A method for preparing said composition consists in that the powder of a pharmaceutical substance is pre-granulated with water or its aqueous solution, the resultant granulate is then subjected to subsequent granulation with a binder solution, dried and powdered with lubricant.
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