Ursodeoxycholic acid-containing medicament in a liquid adminstration form
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United States of America Patent
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-
Jul 9, 1996
Grant Date -
N/A
app pub date -
Aug 25, 1994
filing date -
Aug 30, 1993
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
The active agent ursodeoxycholic acid has proved therapeutically active in infants, inter alia for the treatment of cholestatic hepatic diseases. A problem when administering this active agent, a bile acid, to infants is its extreme bitterness. As a result of the present invention a taste-acceptable, liquid administration form for ursodeoxycholic acid with an adequately high active agent concentration is described. The liquid to be ingested is a suspension prepared accompanied by the addition of a swelling and/or thickening agent, which contains the active agent mainly in fine crystalline form as the disperse phase and only in a much smaller proportion dissolved in the aqueous dispersant. A remaining residual bitterness can be additionally masked by the addition of .beta.-cyclodextrin or suitable taste correcting agents.
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Family
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