Methods for identifying a tyrosine phosphatase abnormality associated with neoplastic disease
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United States of America Patent
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Jul 16, 1996
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app pub date -
Feb 28, 1994
filing date -
Jun 26, 1991
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Abstract
The present invention relates to the isolation of genes encoding novel protein tyrosine phosphatases (PTPs) having SH2 domains, the nucleic acid sequences isolated, and the encoded phosphatases. The invention further relates to methods of altering tyrosine phosphatase activities encoded by the novel phosphatases. By altering (i.e., increasing or decreasing) tyrosine phosphatase activity, one can alter megakaryocyte cell function, and thereby alter platelet production. Alteration of the genes is associated with neoplastic disease.
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